EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
1.6.3.1 | additional information | NADPH oxidase can be activated in a cell-free system by mixing cytosol and plasma membranes isolated from resting neutrophils or macrophages in the presence of Mg2+, GTP and an anionic amphiphile such as arachidonic acid or sodium dodecyl sulfate | Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.6.3.1 | 4-(2-amino-ethyl)-benzolsulphonyl-fluoride | - |
Homo sapiens | |
1.6.3.1 | 4-(2-amino-ethyl)-benzolsulphonyl-fluoride | - |
Rattus norvegicus | |
1.6.3.1 | 4-(2-aminoethyl)-benzenesulfonyl fluoride | - |
Homo sapiens | |
1.6.3.1 | apocynin | poor inhibitor of NADPH oxidase | Homo sapiens | |
1.6.3.1 | apocynin | - |
Rattus norvegicus | |
1.6.3.1 | AYRRNSVRFL | inhibits NADPH oxidase activation | Homo sapiens | |
1.6.3.1 | diphenylene iodonium | - |
Homo sapiens | |
1.6.3.1 | diphenylene iodonium | - |
Rattus norvegicus | |
1.6.3.1 | FAVHHDEEKDVITG | - |
Homo sapiens | |
1.6.3.1 | FLRGSSACCSTRVRRQL | - |
Homo sapiens | |
1.6.3.1 | additional information | trimer hydroxylated quinone is the major active compound in AOP-1, with strong inhibitory activity against vascular endothelial cell NADPH oxidase with an IC50 of 0.000031 mM at 22°C, pH not specified in the publication | Homo sapiens | |
1.6.3.1 | additional information | trimer hydroxylated quinone is the major active compound in AOP-1, with strong inhibitory activity against vascular endothelial cell NADPH oxidase with an IC50 of 0.000031 mM at 22°C, pH not specified in the publication | Rattus norvegicus | |
1.6.3.1 | Phenylarsine oxide | - |
Homo sapiens | |
1.6.3.1 | RGVHFIF | - |
Homo sapiens | |
1.6.3.1 | RSRKRLSQDAYRRNSVRF | inhibits NADPH oxidase activation | Homo sapiens | |
1.6.3.1 | SNSESGPRGVHFIFNKEN | - |
Homo sapiens | |
1.6.3.1 | VAS3947 | i.e. 3-benzyl-7-(2-oxazolyl)thio-1,2,3-triazolo[4,5-d]pyrimidine, specific low micromolar NADPH oxidase inhibitor | Homo sapiens | |
1.6.3.1 | VAS3947 | i.e. 3-benzyl-7-(2-oxazolyl)thio-1,2,3-triazolo[4,5-d]pyrimidine, specific low micromolar NADPH oxidase inhibitor | Rattus norvegicus |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
1.6.3.1 | cytosol | - |
Homo sapiens | 5829 | - |
1.6.3.1 | cytosol | NOX components are distributed between the cytosol (p47phox, p67phox, p40phox and Rac1/2) and the plasma membrane and membranes of specific granules | Homo sapiens | 5829 | - |
1.6.3.1 | membrane | - |
Homo sapiens | 16020 | - |
1.6.3.1 | membrane | NOX components are distributed between the cytosol (p47phox, p67phox, p40phox and Rac1/2) and the plasma membrane and membranes of specific granules | Homo sapiens | 16020 | - |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.6.3.1 | Homo sapiens | - |
- |
- |
1.6.3.1 | Rattus norvegicus | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.6.3.1 | A7r5 cell | - |
Rattus norvegicus | - |
1.6.3.1 | aorta | - |
Rattus norvegicus | - |
1.6.3.1 | Caco-2 cell | - |
Homo sapiens | - |
1.6.3.1 | HL-60 cell | - |
Homo sapiens | - |
1.6.3.1 | HUVEC cell | - |
Homo sapiens | - |
1.6.3.1 | phagocyte | - |
Homo sapiens | - |
1.6.3.1 | umbilical vein | - |
Homo sapiens | - |
1.6.3.1 | vascular endothelial cell | - |
Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.6.3.1 | NADPH + H+ + O2 | - |
Homo sapiens | NADP+ + H2O2 | - |
? | |
1.6.3.1 | NADPH + H+ + O2 | - |
Rattus norvegicus | NADP+ + H2O2 | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.6.3.1 | NADPH oxidase | - |
Homo sapiens |
1.6.3.1 | NADPH oxidase | - |
Rattus norvegicus |
1.6.3.1 | NADPH oxidase | the phagocyte NADPH oxidase is a multicomponent enzyme complex comprising six proteins, namely p22phox (phox: phagocyte oxidase), gp91phox, p47phox, p67phox, p40phox and the small G-protein Rac1 or Rac2 | Homo sapiens |
1.6.3.1 | NOX | - |
Homo sapiens |
1.6.3.1 | NOX | - |
Rattus norvegicus |
1.6.3.1 | NOX1 | isozyme | Homo sapiens |
1.6.3.1 | Nox2 | isozyme | Homo sapiens |
1.6.3.1 | Nox4 | isozyme | Homo sapiens |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.6.3.1 | FAD | - |
Homo sapiens | |
1.6.3.1 | FAD | - |
Rattus norvegicus |
EC Number | General Information | Comment | Organism |
---|---|---|---|
1.6.3.1 | physiological function | NADPH oxidase is a major source of reactive oxygen species in aortas of spontaneously hypertensive rats | Rattus norvegicus |