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Literature summary extracted from

  • El-Benna, J.; Dang, P.M.; Perianin, A.
    Peptide-based inhibitors of the phagocyte NADPH oxidase (2010), Biochem. Pharmacol., 80, 778-785.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.6.3.1 additional information NADPH oxidase can be activated in a cell-free system by mixing cytosol and plasma membranes isolated from resting neutrophils or macrophages in the presence of Mg2+, GTP and an anionic amphiphile such as arachidonic acid or sodium dodecyl sulfate Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.6.3.1 4-(2-amino-ethyl)-benzolsulphonyl-fluoride
-
Homo sapiens
1.6.3.1 4-(2-amino-ethyl)-benzolsulphonyl-fluoride
-
Rattus norvegicus
1.6.3.1 4-(2-aminoethyl)-benzenesulfonyl fluoride
-
Homo sapiens
1.6.3.1 apocynin poor inhibitor of NADPH oxidase Homo sapiens
1.6.3.1 apocynin
-
Rattus norvegicus
1.6.3.1 AYRRNSVRFL inhibits NADPH oxidase activation Homo sapiens
1.6.3.1 diphenylene iodonium
-
Homo sapiens
1.6.3.1 diphenylene iodonium
-
Rattus norvegicus
1.6.3.1 FAVHHDEEKDVITG
-
Homo sapiens
1.6.3.1 FLRGSSACCSTRVRRQL
-
Homo sapiens
1.6.3.1 additional information trimer hydroxylated quinone is the major active compound in AOP-1, with strong inhibitory activity against vascular endothelial cell NADPH oxidase with an IC50 of 0.000031 mM at 22°C, pH not specified in the publication Homo sapiens
1.6.3.1 additional information trimer hydroxylated quinone is the major active compound in AOP-1, with strong inhibitory activity against vascular endothelial cell NADPH oxidase with an IC50 of 0.000031 mM at 22°C, pH not specified in the publication Rattus norvegicus
1.6.3.1 Phenylarsine oxide
-
Homo sapiens
1.6.3.1 RGVHFIF
-
Homo sapiens
1.6.3.1 RSRKRLSQDAYRRNSVRF inhibits NADPH oxidase activation Homo sapiens
1.6.3.1 SNSESGPRGVHFIFNKEN
-
Homo sapiens
1.6.3.1 VAS3947 i.e. 3-benzyl-7-(2-oxazolyl)thio-1,2,3-triazolo[4,5-d]pyrimidine, specific low micromolar NADPH oxidase inhibitor Homo sapiens
1.6.3.1 VAS3947 i.e. 3-benzyl-7-(2-oxazolyl)thio-1,2,3-triazolo[4,5-d]pyrimidine, specific low micromolar NADPH oxidase inhibitor Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.6.3.1 cytosol
-
Homo sapiens 5829
-
1.6.3.1 cytosol NOX components are distributed between the cytosol (p47phox, p67phox, p40phox and Rac1/2) and the plasma membrane and membranes of specific granules Homo sapiens 5829
-
1.6.3.1 membrane
-
Homo sapiens 16020
-
1.6.3.1 membrane NOX components are distributed between the cytosol (p47phox, p67phox, p40phox and Rac1/2) and the plasma membrane and membranes of specific granules Homo sapiens 16020
-

Organism

EC Number Organism UniProt Comment Textmining
1.6.3.1 Homo sapiens
-
-
-
1.6.3.1 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.6.3.1 A7r5 cell
-
Rattus norvegicus
-
1.6.3.1 aorta
-
Rattus norvegicus
-
1.6.3.1 Caco-2 cell
-
Homo sapiens
-
1.6.3.1 HL-60 cell
-
Homo sapiens
-
1.6.3.1 HUVEC cell
-
Homo sapiens
-
1.6.3.1 phagocyte
-
Homo sapiens
-
1.6.3.1 umbilical vein
-
Homo sapiens
-
1.6.3.1 vascular endothelial cell
-
Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.6.3.1 NADPH + H+ + O2
-
Homo sapiens NADP+ + H2O2
-
?
1.6.3.1 NADPH + H+ + O2
-
Rattus norvegicus NADP+ + H2O2
-
?

Synonyms

EC Number Synonyms Comment Organism
1.6.3.1 NADPH oxidase
-
Homo sapiens
1.6.3.1 NADPH oxidase
-
Rattus norvegicus
1.6.3.1 NADPH oxidase the phagocyte NADPH oxidase is a multicomponent enzyme complex comprising six proteins, namely p22phox (phox: phagocyte oxidase), gp91phox, p47phox, p67phox, p40phox and the small G-protein Rac1 or Rac2 Homo sapiens
1.6.3.1 NOX
-
Homo sapiens
1.6.3.1 NOX
-
Rattus norvegicus
1.6.3.1 NOX1 isozyme Homo sapiens
1.6.3.1 Nox2 isozyme Homo sapiens
1.6.3.1 Nox4 isozyme Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.6.3.1 FAD
-
Homo sapiens
1.6.3.1 FAD
-
Rattus norvegicus

General Information

EC Number General Information Comment Organism
1.6.3.1 physiological function NADPH oxidase is a major source of reactive oxygen species in aortas of spontaneously hypertensive rats Rattus norvegicus