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Literature summary extracted from

  • Hemauer, S.J.; Patrikeeva, S.L.; Nanovskaya, T.N.; Hankins, G.D.; Ahmed, M.S.
    Opiates inhibit paclitaxel uptake by P-glycoprotein in preparations of human placental inside-out vesicles (2009), Biochem. Pharmacol., 78, 1272-1278.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
7.6.2.2 buprenorphine inhibits paclitaxel transport, placental brush border membrane vesicles Homo sapiens
7.6.2.2 methadone inhibits paclitaxel transport, placental brush border membrane vesicles Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining

Organism

EC Number Organism UniProt Comment Textmining
7.6.2.2 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
7.6.2.2 placenta placental apical membrane, preparation of brush border membrane inside-out vesicles Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.6.2.2 ATP + H2O + paclitaxel/in
-
 Homo sapiens ADP + phosphate + paclitaxel/out
-
 ?

Synonyms

EC Number Synonyms Comment Organism
7.6.2.2 P-glycoprotein
-
 Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
7.6.2.2 0.018
-
 methadone 22°C, pH 7.4, inhibition of paclitaxel transport Homo sapiens
7.6.2.2 0.044
-
 buprenorphine 22°C, pH 7.4, inhibition of paclitaxel transport Homo sapiens
7.6.2.2 0.09
-
 buprenorphine 22°C, pH 7.4, inhibition of paclitaxel transport Homo sapiens