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Literature summary extracted from

  • Ximenes, V.F.; Maghzal, G.J.; Turner, R.; Kato, Y.; Winterbourn, C.C.; Kettle, A.J.
    Serotonin as a physiological substrate for myeloperoxidase and its superoxide-dependent oxidation to cytotoxic tryptamine-4,5-dione (2010), Biochem. J., 425, 285-293.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.11.2.2 serotonin at low micromolar concentrations (below 0.02 mM), serotonin enhances hypochlorite production by both purified myeloperoxidase and neutrophils Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.11.2.2 serotonin at higher concentrations than 0.02 mM, serotonin almost completely blocks the formation of hypochlorite Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.11.2.2 ascorbate + H2O2 Homo sapiens
-
 ?
-
 ?
1.11.2.2 Br- + H2O2 Homo sapiens
-
 ?
-
 ?
1.11.2.2 Cl- + H2O2 Homo sapiens main reducing substrate for myeloperoxidase HClO + H2O
-
 ?
1.11.2.2 nitric oxide + H2O2 Homo sapiens
-
 ?
-
 ?
1.11.2.2 nitrite + H2O2 Homo sapiens
-
 ?
-
 ?
1.11.2.2 thiocyanate + H2O2 Homo sapiens
-
 hypothiocyanite + H2O
-
 ?
1.11.2.2 tyrosine + H2O2 Homo sapiens
-
 ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.11.2.2 Homo sapiens P05164
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.11.2.2 neutrophil
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.11.2.2 ascorbate + H2O2
-
 Homo sapiens ?
-
 ?
1.11.2.2 Br- + H2O2
-
 Homo sapiens ?
-
 ?
1.11.2.2 Cl- + H2O2 main reducing substrate for myeloperoxidase Homo sapiens HClO + H2O
-
 ?
1.11.2.2 nitric oxide + H2O2
-
 Homo sapiens ?
-
 ?
1.11.2.2 nitrite + H2O2
-
 Homo sapiens ?
-
 ?
1.11.2.2 serotonin + H2O2 favoured substrate of myeloperoxidase, only ascorbate blocks oxidation of serotonin Homo sapiens serotonin dimer + H2O
-
 ?
1.11.2.2 serotonin + superoxide
-
 Homo sapiens tryptamine-4,5-dione + H2O
-
 ?
1.11.2.2 thiocyanate + H2O2
-
 Homo sapiens hypothiocyanite + H2O
-
 ?
1.11.2.2 tyrosine + H2O2
-
 Homo sapiens ?
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.11.2.2 heme
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
1.11.2.2 physiological function oxidation of serotonin by myeloperoxidase may profoundly influence inflammatory processes Homo sapiens