EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
1.13.11.34 | coactosin-like protein | binds 5-LO and promotes leukotriene formation, coactosin-like protein prevents heat-inactivation of 5-LO | Homo sapiens | |
1.13.11.34 | phosphatidylcholine | - |
Homo sapiens |
EC Number | Cloned (Comment) | Organism |
---|---|---|
1.13.11.34 | expressed in Escherichia coli BL21 and MV1190 cells | Homo sapiens |
EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
1.13.11.34 | W102A | the mutation prevents interaction with coactosin-like protein, the mutant shows barely detectable dioxygenase activity | Homo sapiens |
1.13.11.34 | W13A | the mutation upregulates leukotriene production, the enzyme activity of the mutant 5-LO at low concentrations of phosphatidylcholine (0.005 mg/ml) and arachidonic acid (0.02 mM) is reduced compared to the wild type enzyme | Homo sapiens |
1.13.11.34 | W75A | the mutation upregulates leukotriene production, the enzyme activity of the mutant 5-LO at low concentrations of phosphatidylcholine (0.005 mg/ml) and arachidonic acid (0.02 mM) is reduced compared to the wild type enzyme | Homo sapiens |
EC Number | General Stability | Organism |
---|---|---|
1.13.11.34 | coactosin-like protein functions as a stabilizing chaperone for 5-lipoxygenase (preventing non-turnover inactivation) | Homo sapiens |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
1.13.11.34 | nucleus | 5-LO associates with a nuclear fraction only when differentiated cells are primed with phorbol ester and stimulated with ionophore | Homo sapiens | 5634 | - |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
1.13.11.34 | Ca2+ | activates | Homo sapiens |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.13.11.34 | Homo sapiens | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.13.11.34 | Mono-Mac-6 cell | - |
Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.13.11.34 | (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate | - |
Homo sapiens | leukotriene A4 + H2O | - |
? | |
1.13.11.34 | arachidonate + O2 | - |
Homo sapiens | (6E,8Z,11Z,14Z)-(5S)-hydroperoxyicosa-6,8,11,14-tetraenoate | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.13.11.34 | 5-lipoxygenase | - |
Homo sapiens |
1.13.11.34 | 5-LO | - |
Homo sapiens |