BRENDA - Enzyme Database

IDH1(R132) mutation identified in one human melanoma metastasis, but not correlated with metastases to the brain

Lopez, G.Y.; Reitman, Z.J.; Solomon, D.; Waldman, T.; Bigner, D.D.; McLendon, R.E.; Rosenberg, S.A.; Samuels, Y.; Yan, H.; Biochem. Biophys. Res. Commun. 398, 585-587 (2010)

Data extracted from this reference:

Engineering
EC Number
Amino acid exchange
Commentary
Organism
1.1.1.42
R132C
naturally occuring mutation of IDH1 in melanoma metastasis of the lung
Homo sapiens
1.1.1.42
R132X
naturally occuring mutation of IDH1 in metastatic brain tumors
Homo sapiens
1.1.1.42
R172X
naturally occuring mutations of IDH2 in metastatic brain tumors
Homo sapiens
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
1.1.1.42
isocitrate + NADP+
Homo sapiens
-
2-oxoglutarate + NADPH + H+ + CO2
-
-
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
1.1.1.42
Homo sapiens
O75874
IDH1
-
1.1.1.42
Homo sapiens
P48735
IDH2
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
1.1.1.42
glioma cell
progressive gliomas; progressive gliomas
Homo sapiens
-
1.1.1.42
melanoma cell
;
Homo sapiens
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.1.1.42
isocitrate + NADP+
-
711107
Homo sapiens
2-oxoglutarate + NADPH + H+ + CO2
-
-
-
?
Cofactor
EC Number
Cofactor
Commentary
Organism
Structure
1.1.1.42
NADP+
;
Homo sapiens
Cofactor (protein specific)
EC Number
Cofactor
Commentary
Organism
Structure
1.1.1.42
NADP+
-
Homo sapiens
Engineering (protein specific)
EC Number
Amino acid exchange
Commentary
Organism
1.1.1.42
R132C
naturally occuring mutation of IDH1 in melanoma metastasis of the lung
Homo sapiens
1.1.1.42
R132X
naturally occuring mutation of IDH1 in metastatic brain tumors
Homo sapiens
1.1.1.42
R172X
naturally occuring mutations of IDH2 in metastatic brain tumors
Homo sapiens
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
1.1.1.42
isocitrate + NADP+
Homo sapiens
-
2-oxoglutarate + NADPH + H+ + CO2
-
-
?
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
1.1.1.42
glioma cell
progressive gliomas
Homo sapiens
-
1.1.1.42
melanoma cell
-
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.1.1.42
isocitrate + NADP+
-
711107
Homo sapiens
2-oxoglutarate + NADPH + H+ + CO2
-
-
-
?
General Information
EC Number
General Information
Commentary
Organism
1.1.1.42
physiological function
elective pressures in the brain environment may specifically favor the cell growth or survival of tumor cells with mutations in IDH1, regardless of primary tumor site; elective pressures in the brain environment may specifically favor the cell growth or survival of tumor cells with mutations in IDH2, regardless of primary tumor site
Homo sapiens
General Information (protein specific)
EC Number
General Information
Commentary
Organism
1.1.1.42
physiological function
elective pressures in the brain environment may specifically favor the cell growth or survival of tumor cells with mutations in IDH2, regardless of primary tumor site
Homo sapiens
1.1.1.42
physiological function
elective pressures in the brain environment may specifically favor the cell growth or survival of tumor cells with mutations in IDH1, regardless of primary tumor site
Homo sapiens