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Literature summary extracted from

  • Liu, Z.B.; Shen, X.
    Thioredoxin reductase 1 upregulates MCP-1 release in human endothelial cells (2009), Biochem. Biophys. Res. Commun., 386, 703-708.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.8.1.9 thioredoxin disulfide + NADPH + H+ Homo sapiens
-
 thioredoxin + NADP+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.8.1.9 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.8.1.9 EAhy926 cell
-
 Homo sapiens
-
1.8.1.9 endothelial cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.8.1.9 thioredoxin disulfide + NADPH + H+
-
 Homo sapiens thioredoxin + NADP+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.8.1.9 thioredoxin reductase 1
-
 Homo sapiens
1.8.1.9 TrxR1
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.8.1.9 NADPH
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
1.8.1.9 physiological function thioredoxin reductase 1 overexpression upregulates monocyte chemoattractant protein-1 release in human endothelial cells by 34%. TrxR1 enhances reactive oxygen species generation, NF-kappaB activity and subsequent monocyte chemoattractant protein-1 expression in endothelial cells, and may promote rather than prevent vascular endothelium from forming atherosclerotic plaque Homo sapiens