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Literature summary extracted from

  • Contreras Ndel, P.; Vasquez, C.C.
    Tellurite-induced carbonylation of the Escherichia coli pyruvate dehydrogenase multienzyme complex (2010), Arch. Microbiol., 192, 969-973.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.2.1.104 tellurite pyruvate dehydrogenase activity decreases by 81% after tellurite treatment (0.0005 mg/ml for 30 min) Escherichia coli

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.2.1.104 additional information Escherichia coli the PDH complex irreversibly decarboxylates pyruvate to acetylCoA (PDH activity) in a reaction that involves the participation of the three enzymes forming the PDH complex: AceE (pyruvate decarboxylase), AceF (dihydrolipoil acetyltransferase) and Lpd (dihydrolipoil dehydrogenase) ?
-
 ?
1.2.1.104 additional information Escherichia coli BW25113 the PDH complex irreversibly decarboxylates pyruvate to acetylCoA (PDH activity) in a reaction that involves the participation of the three enzymes forming the PDH complex: AceE (pyruvate decarboxylase), AceF (dihydrolipoil acetyltransferase) and Lpd (dihydrolipoil dehydrogenase) ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.104 Escherichia coli
-
-
-
1.2.1.104 Escherichia coli BW25113
-
-
-

Oxidation Stability

EC Number Oxidation Stability Organism
1.2.1.104 pyruvate dehydrogenase activity decreases by 88% after H2O2 treatment (2.5 mM for 30 min) Escherichia coli

Purification (Commentary)

EC Number Purification (Comment) Organism
1.2.1.104 Ni2+-Sepharose column chromatography Escherichia coli

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.104 additional information the PDH complex irreversibly decarboxylates pyruvate to acetylCoA (PDH activity) in a reaction that involves the participation of the three enzymes forming the PDH complex: AceE (pyruvate decarboxylase), AceF (dihydrolipoil acetyltransferase) and Lpd (dihydrolipoil dehydrogenase) Escherichia coli ?
-
 ?
1.2.1.104 additional information the PDH complex irreversibly decarboxylates pyruvate to acetylCoA (PDH activity) in a reaction that involves the participation of the three enzymes forming the PDH complex: AceE (pyruvate decarboxylase), AceF (dihydrolipoil acetyltransferase) and Lpd (dihydrolipoil dehydrogenase) Escherichia coli BW25113 ?
-
 ?
1.2.1.104 pyruvate + CoA + NAD+
-
 Escherichia coli acetyl-CoA + CO2 + NADH
-
 ir
1.2.1.104 pyruvate + CoA + NAD+
-
 Escherichia coli BW25113 acetyl-CoA + CO2 + NADH
-
 ir

Synonyms

EC Number Synonyms Comment Organism
1.2.1.104 PDH complex
-
 Escherichia coli
1.2.1.104 pyruvate dehydrogenase complex the complex displays two distinct enzymatic activities: pyruvate dehydrogenase and tellurite reductase Escherichia coli

Cofactor

EC Number Cofactor Comment Organism Structure
1.2.1.104 NAD+
-
 Escherichia coli
1.2.1.104 thiamine diphosphate
-
 Escherichia coli