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Literature summary extracted from

  • Tibodeau, J.; Benson, L.; Isham, C.; Owen, W.; Bible, K.
    The anticancer agent chaetocin is a competitive substrate and inhibitor of thioredoxin reductase (2009), Antioxid. Redox Signal., 11, 1097-1106.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.8.1.9 chaetocin competitive inhibitor with anticancer effects, complete inhibition at 0.015 mM Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.8.1.9 0.0046
-
chaetocin in 100 mM potassium phosphate (pH 7.0), at 22°C Homo sapiens
1.8.1.9 0.0161
-
chetomin in 100 mM potassium phosphate (pH 7.0), at 22°C Homo sapiens
1.8.1.9 0.0169
-
gliotoxin in 100 mM potassium phosphate (pH 7.0), at 22°C Homo sapiens
1.8.1.9 0.1047
-
thioredoxin in 100 mM potassium phosphate (pH 7.0), at 22°C Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.8.1.9 thioredoxin disulfide + NADPH + H+ Homo sapiens
-
thioredoxin + NADP+
-
r

Organism

EC Number Organism UniProt Comment Textmining
1.8.1.9 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.8.1.9 HeLa cell
-
Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.8.1.9 5,5'-dithiobis(2-nitrobenzoic acid) + NADPH + H+
-
Homo sapiens thionitrobenzoic acid + NADP+
-
?
1.8.1.9 chaetocin + NADPH + H+ competitive and selective substrate for TrxR1 Homo sapiens ?
-
?
1.8.1.9 chetomin + NADPH + H+
-
Homo sapiens ?
-
?
1.8.1.9 gliotoxin + NADPH + H+
-
Homo sapiens ?
-
?
1.8.1.9 thioredoxin disulfide + NADPH + H+
-
Homo sapiens thioredoxin + NADP+
-
r

Synonyms

EC Number Synonyms Comment Organism
1.8.1.9 thioredoxin reductase-1
-
Homo sapiens
1.8.1.9 TrxR1
-
Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.8.1.9 FAD
-
Homo sapiens
1.8.1.9 NADPH
-
Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.8.1.9 0.004
-
using 5,5'-dithiobis(2-nitrobenzoic acid) as substrate, in 100 mM potassium phosphate (pH 7.0), at 22°C Homo sapiens chaetocin

General Information

EC Number General Information Comment Organism
1.8.1.9 metabolism the TrxR/thioredoxin pathway is of central importance in limiting cellular reactive oxygen species Homo sapiens