EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.8.1.9 | chaetocin | competitive inhibitor with anticancer effects, complete inhibition at 0.015 mM | Homo sapiens |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.8.1.9 | 0.0046 | - |
chaetocin | in 100 mM potassium phosphate (pH 7.0), at 22°C | Homo sapiens | |
1.8.1.9 | 0.0161 | - |
chetomin | in 100 mM potassium phosphate (pH 7.0), at 22°C | Homo sapiens | |
1.8.1.9 | 0.0169 | - |
gliotoxin | in 100 mM potassium phosphate (pH 7.0), at 22°C | Homo sapiens | |
1.8.1.9 | 0.1047 | - |
thioredoxin | in 100 mM potassium phosphate (pH 7.0), at 22°C | Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.8.1.9 | thioredoxin disulfide + NADPH + H+ | Homo sapiens | - |
thioredoxin + NADP+ | - |
r |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.8.1.9 | Homo sapiens | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.8.1.9 | HeLa cell | - |
Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.8.1.9 | 5,5'-dithiobis(2-nitrobenzoic acid) + NADPH + H+ | - |
Homo sapiens | thionitrobenzoic acid + NADP+ | - |
? | |
1.8.1.9 | chaetocin + NADPH + H+ | competitive and selective substrate for TrxR1 | Homo sapiens | ? | - |
? | |
1.8.1.9 | chetomin + NADPH + H+ | - |
Homo sapiens | ? | - |
? | |
1.8.1.9 | gliotoxin + NADPH + H+ | - |
Homo sapiens | ? | - |
? | |
1.8.1.9 | thioredoxin disulfide + NADPH + H+ | - |
Homo sapiens | thioredoxin + NADP+ | - |
r |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.8.1.9 | thioredoxin reductase-1 | - |
Homo sapiens |
1.8.1.9 | TrxR1 | - |
Homo sapiens |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.8.1.9 | FAD | - |
Homo sapiens | |
1.8.1.9 | NADPH | - |
Homo sapiens |
EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|---|
1.8.1.9 | 0.004 | - |
using 5,5'-dithiobis(2-nitrobenzoic acid) as substrate, in 100 mM potassium phosphate (pH 7.0), at 22°C | Homo sapiens | chaetocin |
EC Number | General Information | Comment | Organism |
---|---|---|---|
1.8.1.9 | metabolism | the TrxR/thioredoxin pathway is of central importance in limiting cellular reactive oxygen species | Homo sapiens |