Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Jiang, S.S.; Lin, T.Y.; Wang, W.B.; Liu, M.C.; Hsueh, P.R.; Liaw, S.J.
    Characterization of UDP-glucose dehydrogenase and UDP-glucose pyrophosphorylase mutants of Proteus mirabilis: defectiveness in polymyxin B resistance, swarming, and virulence (2010), Antimicrob. Agents Chemother., 54, 2000-2009.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
1.1.1.22 additional information construction by Tn5 transposon mutagenesis of a knockout mutant of ugd, that is extremely sensitive to polymyxin B, presumably because of alterations in lipopolysaccharide structure and cell surface architecture in the mutant. The mutant is defective in swarming, expresses lower levels of virulence factor hemolysin, and has lower cell invasion ability. Complementation of the ugd or galU mutant with the full-length ugd gene leads to the restoration of wild-type phenotypic traits, phenotype, overview Proteus mirabilis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.22 UDP-glucose + 2 NAD+ + H2O Proteus mirabilis
-
 UDP-glucuronic acid + 2 NADH + 2 H+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.22 Proteus mirabilis C3VI43 gene ugd
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.22 UDP-glucose + 2 NAD+ + H2O
-
 Proteus mirabilis UDP-glucuronic acid + 2 NADH + 2 H+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.22 UDP-glucose dehydrogenase
-
 Proteus mirabilis
1.1.1.22 Ugd
-
 Proteus mirabilis

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.22 NAD+
-
 Proteus mirabilis

Expression

EC Number Organism Comment Expression
1.1.1.22 Proteus mirabilis expression of Ugd is induced by polymyxin B through RppA, a putative response regulator of the bacterial two-component system up

General Information

EC Number General Information Comment Organism
1.1.1.22 additional information mutation in either ugd leads to activation of RpoE, an extracytoplasmic function sigma factor that is activated by protein misfolding and alterations in cell surface structure in other bacteria. Activation of RpoE or RpoE overexpression causes inhibition of FlhDC and hemolysin expression Proteus mirabilis