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Literature summary extracted from

  • Shimizu, K.; Murata, T.; Watanabe, Y.; Sato, C.; Morita, H.; Tagawa, T.
    Characterization of phosphodiesterase 1 in human malignant melanoma cell lines (2009), Anticancer Res., 29, 1119-1122.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.4.1 full open reading frames for PDE1C1 and PDE1C3 are cloned Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.4.1 vinpocetin 10 mU, surpresses the increase of activity, caused by the addition of 0.2 mM Ca2+ Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.1.4.1 Ca2+ 0.2 mM activity in MAA cells stimulated ca. 2fold, with calmodulin Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.1 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.1 melanoma cell line human malignant melanoma MAA cell line Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.1 cAMP + H2O incubated with or without 0.2 mM CaCl2, 10 mU calmodulin, and PDE1 inhibitor vinpocetin, 30°C, pH 7.5 Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.4.1 PDE1
-
 Homo sapiens
3.1.4.1 phosphodiesterase 1
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.1.4.1 30
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.4.1 7.5
-
 assay at Homo sapiens

Expression

EC Number Organism Comment Expression
3.1.4.1 Homo sapiens PDE1 mRNA expression is investigated additional information