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Literature summary extracted from
- Differing views of the role of selenium in thioredoxin reductase (2011), Amino Acids, 41, 73-89.
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 1.8.1.9 | cytosol | - |
Rattus norvegicus | 5829 | - |
| 1.8.1.9 | mitochondrion | - |
Mus musculus | 5739 | - |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.8.1.9 | selenium | the enzyme possesses selenium in the form of selenocysteine in the active site | Mus musculus |  |
| 1.8.1.9 | selenium | the enzyme possesses selenium in the form of selenocysteine in the active site | Rattus norvegicus | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.8.1.9 | thioredoxin disulfide + NADPH + H+ | Mus musculus | - |
thioredoxin + NADP+ | - |
? | |
| 1.8.1.9 | thioredoxin disulfide + NADPH + H+ | Rattus norvegicus | - |
thioredoxin + NADP+ | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.8.1.9 | Mus musculus | - |
- |
- |
| 1.8.1.9 | Rattus norvegicus | - |
- |
- |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.8.1.9 | 5,5'-dithiobis-(2-nitrobenzoic acid) + NADPH + H+ | - |
Rattus norvegicus | ? | - |
? | |
| 1.8.1.9 | juglone + NADPH + H+ | - |
Rattus norvegicus | ? | - |
? | |
| 1.8.1.9 | lipoic acid + NADPH + H+ | - |
Mus musculus | ? | - |
? | |
| 1.8.1.9 | selenite + NADPH + H2O | - |
Mus musculus | Se2- + NADP+ + ? | - |
? | |
| 1.8.1.9 | thioredoxin disulfide + NADPH + H+ | - |
Mus musculus | thioredoxin + NADP+ | - |
? | |
| 1.8.1.9 | thioredoxin disulfide + NADPH + H+ | - |
Rattus norvegicus | thioredoxin + NADP+ | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.8.1.9 | thioredoxin reductase | - |
Mus musculus |
| 1.8.1.9 | thioredoxin reductase | - |
Rattus norvegicus |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.8.1.9 | FAD | - |
Mus musculus | |
| 1.8.1.9 | FAD | - |
Rattus norvegicus | |
| 1.8.1.9 | NADPH | - |
Mus musculus | |
| 1.8.1.9 | NADPH | - |
Rattus norvegicus | |
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Release 2023.1 (January 2023)
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