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Literature summary extracted from

  • Pezzato, E.; Battaglia, V.; Brunati, A.; Agostinelli, E.; Toninello, A.
    Ca2+-independent effects of spermine on pyruvate dehydrogenase complex activity in energized rat liver mitochondria incubated in the absence of exogenous Ca2+ and Mg2+ (2009), Amino Acids, 36, 449-456.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.2.1.104 additional information the E1alpha subunit of PDC regulates the activity of the complex Rattus norvegicus
1.2.1.104 spermine in the absence of exogenous Ca2+ and Mg2+ and in the presence of EGTA, which favours the release of endogenous Ca2+, spermine is able to stimulate the activity of pyruvate dehydrogenase complex (maximum stimulation of about 140% at 0.5 mM after 30 min of incubation, at concentrations higher than 0.5 mM, spermine still stimulates PDC, when compared with the control, but shows a slight dose-dependent decrease). The interaction of spermine with PDC may also involve activation of pyruvate dehydrogenase kinase, resulting in an increase in E1alpha phosphorylation and consequently reduced stimulation of PDC at high polyamine concentrations Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.2.1.104 mitochondrion
-
 Rattus norvegicus 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.2.1.104 pyruvate + CoA + NAD+ Rattus norvegicus
-
 acetyl-CoA + CO2 + NADH
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.104 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.2.1.104 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.104 pyruvate + CoA + NAD+
-
 Rattus norvegicus acetyl-CoA + CO2 + NADH
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.2.1.104 PDC
-
 Rattus norvegicus
1.2.1.104 pyruvate dehydrogenase complex
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.2.1.104 NAD+
-
 Rattus norvegicus
1.2.1.104 thiamine diphosphate
-
 Rattus norvegicus