Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Hisar, O.; Sönmez, A.; Beydemir, A.; Hisar, A.; Yanik, T.; Cronin, T.
    Kinetic behaviour of glucose 6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase in different tissues of rainbow trout (Oncorhynchus mykiss) exposed to non-lethal concentrations of cadmium (2009), Acta Vet. Brno, 78, 179-185.
No PubMed abstract available

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.1.1.43 Cd2+ the activity of 6PGD is stimulated after three days in the liver at a dose of 1 mg/l Cd and on the first day in gill, liver and kidney tissues at doses of 3 and 5 mg/l Cd. The stimulation effect of the 5 mg/l dose of Cd on G6PD and 6PGD enzyme activities is significantly diminished Oncorhynchus mykiss
1.1.1.49 Cd2+ enzyme is stimulated in presence of 3 mg and 5 mg of Cd on the first day of experiment in gill, liver and kidney tissues. The stimulation effect of the 5 mg/l dose of Cd on G6PD and 6PGD enzyme activities is significantly diminished after seven days. The G6PDenzyme activity levels are stimulated by approximately 60% in gills, 68% in liver, and 67% in kidneys Oncorhynchus mykiss

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.43 Oncorhynchus mykiss
-
-
-
1.1.1.49 Oncorhynchus mykiss
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.43 gill
-
 Oncorhynchus mykiss
-
1.1.1.43 kidney
-
 Oncorhynchus mykiss
-
1.1.1.43 liver
-
 Oncorhynchus mykiss
-
1.1.1.49 gill enzyme is stimulated in presence of 3 mg and 5 mg of Cd on the first day of experiment in gill, liver and kidney tissues. The stimulation effect of the 5 mg/l dose of Cd on G6PD and 6PGD enzyme activities is significantly diminished after seven days. The G6PD enzyme activity levels are stimulated by approximately 60% in gills Oncorhynchus mykiss
-
1.1.1.49 kidney enzyme activity of G6PD enzyme is significantly stimulated after three days in liver and kidney tissues at a dose of 1 mg/l Cdand is stimulated on the first day of experiment in gill, liver and kidney tissues at doses of 3 and 5 mg/l Cd. The stimulation effect of the 5 mg/l dose of Cd on G6PD and 6PGD enzyme activities is significantly diminished after seven days. The G6PDenzyme activity levels are stimulated by approximately 67% in kidney Oncorhynchus mykiss
-
1.1.1.49 liver enzyme activity of G6PD enzyme is significantly stimulated after three days in liver and kidney tissues at a dose of 1 mg/l Cd and is stimulated on the first day of experiment in gill, liver and kidney tissues at doses of 3 and 5 mg/l Cd. The stimulation effect of the 5 mg/l dose of Cd on G6PD and 6PGD enzyme activities is significantly diminished after seven days. The G6PDenzyme activity levels are stimulated by approximately 68% in liver Oncorhynchus mykiss
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.43 6-phospho-D-gluconate + NADP+
-
 Oncorhynchus mykiss 6-phospho-2-dehydro-D-gluconate + NADPH + H+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.43 6PGDH
-
 Oncorhynchus mykiss

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.1.1.43 25
-
 assay at Oncorhynchus mykiss

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.1.43 8
-
 assay at Oncorhynchus mykiss

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.43 NADPH
-
 Oncorhynchus mykiss

General Information

EC Number General Information Comment Organism
1.1.1.43 physiological function 6PGD enzymes functions to protect against cadmium toxicity Oncorhynchus mykiss