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Literature summary extracted from

  • Arachea, B.T.; Liu, X.; Pavlovsky, A.G.; Viola, R.E.
    Expansion of the aspartate beta-semialdehyde dehydrogenase family: the first structure of a fungal ortholog (2010), Acta Crystallogr. Sect. D, 66, 205-212.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.2.1.11 expressed in Escherichia coli BL21 cells Candida albicans

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
1.2.1.11 hanging drop vapor diffusion method, using 20% (w/v) PEG 400, 0.1 M HEPES pH 6.5, 0.1 M MgCl2, at 20°C Candida albicans

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.2.1.11 L-aspartate 4-semialdehyde + phosphate + NADP+ Candida albicans
-
L-4-aspartyl phosphate + NADPH + H+
-
?

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.11 Candida albicans Q5ALM0
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.2.1.11 cobalt immobilized metal-affinity column chromatography and Source 30Q column chromatography Candida albicans

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.11 L-aspartate 4-semialdehyde + phosphate + NADP+
-
Candida albicans L-4-aspartyl phosphate + NADPH + H+
-
?

Subunits

EC Number Subunits Comment Organism
1.2.1.11 homodimer x-ray crystallography Candida albicans

Synonyms

EC Number Synonyms Comment Organism
1.2.1.11 ASADH
-
Candida albicans
1.2.1.11 aspartate semialdehyde dehydrogenase
-
Candida albicans

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.2.1.11 0.12
-
L-aspartate 4-semialdehyde pH and temperature not specified in the publication Candida albicans

Cofactor

EC Number Cofactor Comment Organism Structure
1.2.1.11 NADP+
-
Candida albicans