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Literature summary extracted from
- Dilatation of the ascending aorta is associated with low serum prolidase activity (2010), Tohoku J. Exp. Med., 220, 273-277.
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 3.4.13.9 | cytosol | - |
Homo sapiens | 5829 | - |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.13.9 | Mn2+ | activates | Homo sapiens |  |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.13.9 | Homo sapiens | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.4.13.9 | aorta | enzyme activity is increased in aortic dilatation compared to controls | Homo sapiens | - |
| 3.4.13.9 | serum | - |
Homo sapiens | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 3.4.13.9 | additional information | - |
prolidase activity in correlation to aorta diameter, overview | Homo sapiens |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.13.9 | Gly-L-Pro + H2O | - |
Homo sapiens | Gly + L-Pro | - |
? | |
| 3.4.13.9 | additional information | prolidase is an exopeptidase cleaving C-terminally proline and hydroxyproline from iminodipeptides | Homo sapiens | ? | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.4.13.9 | prolidase | - |
Homo sapiens |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 3.4.13.9 | 37 | - |
assay at | Homo sapiens |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.4.13.9 | 7 | - |
assay at | Homo sapiens |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 3.4.13.9 | malfunction | enzyme activity is increased in aortic dilatation compared to controls | Homo sapiens |
| 3.4.13.9 | metabolism | prolidase catalyzes the final step of collgane breakdown, releasing free proline for collagen recycling | Homo sapiens |
| 3.4.13.9 | physiological function | prolidase activity may be a step-limiting factor in the regulation of collagen biosynthesis | Homo sapiens |
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Release 2023.1 (January 2023)
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