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Literature summary extracted from
- Fine epitope mapping of monoclonal antibodies 9B9 and 3G8 to the N domain of angiotensin-converting enzyme (CD143) defines a region involved in regulating angiotensin-converting enzyme dimerization and shedding (2010), Tissue Antigens, 75, 136-150.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 3.4.15.1 | expression of soluble wild-type and mutant enzymes in CHO and HEK-293 cells | Homo sapiens |
Protein Variants
| EC Number | Protein Variants | Comment | Organism |
|---|---|---|---|
| 3.4.15.1 | L19E | the mutation alters the binding of monoclonal antibodies to the N domain of ACE and shedding of ACE domains | Homo sapiens |
| 3.4.15.1 | Q18H | the mutation alters the binding of monoclonal antibodies to the N domain of ACE and shedding of ACE domains | Homo sapiens |
| 3.4.15.1 | Q22A | the mutation alters the binding of monoclonal antibodies to the N domain of ACE and shedding of ACE domains | Homo sapiens |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.15.1 | EDTA | - |
Homo sapiens |  |
| 3.4.15.1 | lisinopril | - |
Homo sapiens | |
| 3.4.15.1 | additional information | monoclonal antibosies mAbs 9B9 and 3G8 prevent ACE dimerization in vitro in reverse micelles, and only mAb 3G8 inhibits ACE shedding from the cell surface | Homo sapiens |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 3.4.15.1 | extracellular | - |
Homo sapiens | - |
- |
| 3.4.15.1 | membrane | cell surface | Homo sapiens | 16020 | - |
| 3.4.15.1 | additional information | ACE undergoes domain shedding and changes from membrane to soluble status | Homo sapiens | - |
- |
| 3.4.15.1 | soluble | - |
Homo sapiens | - |
- |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.15.1 | Zn2+ | ACE is a zinc-metalloprotease | Homo sapiens | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.15.1 | Homo sapiens | P12821 | - |
- |
Posttranslational Modification
| EC Number | Posttranslational Modification | Comment | Organism |
|---|---|---|---|
| 3.4.15.1 | glycoprotein | - |
Homo sapiens |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.4.15.1 | ascites fluid | - |
Homo sapiens | - |
| 3.4.15.1 | kidney | - |
Homo sapiens | - |
| 3.4.15.1 | lung | - |
Homo sapiens | - |
| 3.4.15.1 | plasma | - |
Homo sapiens | - |
| 3.4.15.1 | semen | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.15.1 | hippuryl-His-Leu + H2O | - |
Homo sapiens | hippuric acid + His-Leu | - |
? | |
| 3.4.15.1 | Z-phenylalanyl-histidyl-leucine + H2O | - |
Homo sapiens | Z-phenylalanine + histidyl-leucine | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 3.4.15.1 | dimer | the N domain of ACE influences domain shedding and enzyme dimerization, overview. Epitope mapping using monoclonal antibodies directed to the N domain of ACE, overview | Homo sapiens |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.4.15.1 | ACE | - |
Homo sapiens |
| 3.4.15.1 | angiotensin-I-converting enzyme | - |
Homo sapiens |
| 3.4.15.1 | CD143 | - |
Homo sapiens |
| 3.4.15.1 | peptidyl dipeptidase | - |
Homo sapiens |
| 3.4.15.1 | sACE | - |
Homo sapiens |
| 3.4.15.1 | somatic ACE | - |
Homo sapiens |
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