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Literature summary extracted from

  • Korotaeva, A.A.; Samoilova, E.V.; Piksina, G.F.; Prokazova, N.V.
    Oxidized phosphatidylcholine stimulates activity of secretory phospholipase A2 group IIA and abolishes sphingomyelin-induced inhibition of the enzyme (2010), Prostaglandins Other Lipid Mediat., 91, 38-41.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.1.4 additional information free L-alpha-dipalmitoyl phosphatidylcholine (in liposomes) and low density lipoprotein-incorporated L-alpha-dipalmitoyl phosphatidylcholine have no effect on the enzyme activity Homo sapiens
3.1.1.4 oxidized palmitoyl arachidonyl phosphatidylcholine either added to the assay medium as separated liposomes or incorporated in varied amounts into low density lipoprotein progressively enhances the activity of purified sPLA2(IIA) Homo sapiens

Application

EC Number Application Comment Organism
3.1.1.4 drug development influence on regulation of sPLA2(IIA) activity can be useful in the development of new therapeutic approaches to the treatment of cardiovascular diseases Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.1.4 sphingomyelin suppresses the activating effect of oxidized palmitoyl arachidonyl phosphatidylcholine in a dose-dependent manner, abolishing it almost completely at a concentration 8times as high as that of oxidized palmitoyl arachidonyl phosphatidylcholine. Oxidized palmitoyl arachidonyl phosphatidylcholine completely abolishes the inhibitory effect of low density lipoprotein-incorporated sphingomyelin on the enzyme activity at the oxidized palmitoyl arachidonyl phosphatidylcholine/sphingomyelin concentration ratio 1:2 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.4 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.1.1.4
-
 Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.4 additional information cardiac myxoma Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.4 L-alpha-dipalmitoyl phosphatidylcholine + H2O
-
 Homo sapiens 1-palmitoyl-sn-glycerophosphocholine + palmitate
-
 ?
3.1.1.4 oxidized palmitoyl arachidonyl phosphatidylcholine + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.1.4 secretory phospholipase A2 group IIA
-
 Homo sapiens
3.1.1.4 sPLA2(IIA)
-
 Homo sapiens