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Literature summary extracted from

  • Maas, C.; Meijers, J.C.; Marquart, J.A.; Bakhtiari, K.; Weeterings, C.; de Groot, P.G.; Urbanus, R.T.
    Activated factor V is a cofactor for the activation of factor XI by thrombin in plasma (2010), Proc. Natl. Acad. Sci. USA, 107, 9083-9087.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.21.27 thrombin activated factor V is a cofactor for the activation of factor XI by thrombin. Depletion of factor V, or the addition of activated protein C, decreases the activation of the intrinsic pathway by thrombin in plasma. Factor XI binds to factor V with multiple binding sites. Addition of FVIIIa, kininogen, or protein S does not influence the formation of activated factor XI Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.21.27 individual apple domains of FXI with a tPA-tag Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.27 Homo sapiens P03951
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.21.27
-
Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.27 blood plasma
-
Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.27 pefachrome Xa + H2O
-
Homo sapiens ?
-
?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.27 factor XI
-
Homo sapiens
3.4.21.27 FXI
-
Homo sapiens