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Literature summary extracted from

  • Koharudin, L.M.; Liu, H.; Di Maio, R.; Kodali, R.B.; Graham, S.H.; Gronenborn, A.M.
    Cyclopentenone prostaglandin-induced unfolding and aggregation of the Parkinson disease-associated UCH-L1 (2010), Proc. Natl. Acad. Sci. USA, 107, 6835-6840.
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
3.4.19.12 C132A site-directed mutagenesis, the mutant behaves similar to the wild-type enzyme Homo sapiens
3.4.19.12 C152A site-directed mutagenesis, removal of the C152 thiol group by mutation renders the protein refractory to attack by 15-deoxy-DELTA12,14-prostaglandin J2 Homo sapiens
3.4.19.12 C201A site-directed mutagenesis, the mutant behaves similar to the wild-type enzyme Homo sapiens
3.4.19.12 C220A site-directed mutagenesis, the mutant behaves similar to the wild-type enzyme Homo sapiens
3.4.19.12 C47A site-directed mutagenesis, the mutant behaves similar to the wild-type enzyme Homo sapiens
3.4.19.12 C90A site-directed mutagenesis, the mutant behaves similar to the wild-type enzyme Homo sapiens
3.4.19.12 I93M the UCH-L1 mutant is associated with Parkinson's disease. The mutant enzyme protein is well-folded, structurally similar to the wild-type protein, and aggregates upon conjugation by cyclopentenone prostaglandins Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.19.12 15-deoxy-DELTA12,14-prostaglandin J2 modification of UCH-L1 by cyclopentenone prostaglandins causes unfolding and aggregation. A single thiol group on Cys152 reacts with the alpha,beta-unsaturated carbonyl center in the cyclopentenone ring of prostaglandins, resulting in a covalent adduct, spectral analysis, overview Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.19.12 25902
-
 x * 25902, UCH-L1, mass spectrometry Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.4.19.12 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.19.12 additional information UCH-L1 is present in neurofibrillary tangles or Lewy bodies Homo sapiens
-

Subunits

EC Number Subunits Comment Organism
3.4.19.12 ? x * 25902, UCH-L1, mass spectrometry Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
3.4.19.12 UCH-L1
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
3.4.19.12 malfunction UCH-L1 is implicated in Parkinson’s disease and is present in neurofibrillary tangles or Lewy bodies Homo sapiens