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Literature summary extracted from

  • Shin, D.H.; Chun, Y.S.; Lee, K.H.; Shin, H.W.; Park, J.W.
    Arrest defective-1 controls tumor cell behavior by acetylating myosin light chain kinase (2009), PLoS ONE, 4, e7451.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.18 human arrest defective-1 human arrest defective-1 is a bona fide regulator of MLCK, human arrest defective-1 associates with an IgG motif of MLCK and acetylates the Lys-608 residue in this motif and by so doing deactivates MLCK Homo sapiens
2.7.11.18 ML-7
-
 Homo sapiens
2.7.11.18 ML-9
-
 Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.18 Ca2+ activates Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.18 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.18 HEK-293 cell
-
 Homo sapiens
-
2.7.11.18 HT-1080 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.18 ATP + myosin light chain
-
 Homo sapiens ADP + myosin light chain phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.18 MLCK
-
 Homo sapiens
2.7.11.18 myosin light chain kinase
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.18 ATP
-
 Homo sapiens
2.7.11.18 Calmodulin
-
 Homo sapiens