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Literature summary extracted from

  • Schaefer, M.; Steringer, J.P.; Lyko, F.
    The Drosophila cytosine-5 methyltransferase Dnmt2 is associated with the nuclear matrix and can access DNA during mitosis (2008), PLoS One, 3, e1414.
    View publication on PubMedView publication on EuropePMC

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.1.1.204 cytoplasm Dnmt2 is both a cytoplasmic and a nuclear protein Drosophila melanogaster 5737
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2.1.1.204 nucleus Dnmt2 is both a cytoplasmic and a nuclear protein. A significant amount of Dnmt2 is bound to the nuclear matrix. Dnmt2-EGFP(enhanced-green-fluorescent-protein) enters prophase nuclei and shows a spindle-like localization pattern during mitotic divisions. This localization is microtubule dependent. Dnmt2 can access DNA during mitotic cell divisions Drosophila melanogaster 5634
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Organism

EC Number Organism UniProt Comment Textmining
2.1.1.204 Drosophila melanogaster
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-
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.204 blastocyst
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 Drosophila melanogaster
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2.1.1.204 embryo ubiquitously expressed during early embryogenesis. Expression remains ubiquitous throughout development with enrichment in the foregut and hindgut as well as in the developing mesoderm in gastrulating embryos. Dnmt2 proteins are enriched in actively dividing cells. Dnmt2 localization is highly dynamic during the cell cycle Drosophila melanogaster
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2.1.1.204 germ cell Dnmt2-EGFP is highly expressed in the germarium, blastocyst and cyst stages of the female germ line with the exception of follicle cells. Dnmt2-EGFP is mostly present in the cytoplasm but can also be found in nurse cell nuclei. In the male germ line, Dnmt2-EGFP is expressed in most cells, including stem cells as well as in maturing spermatocytes with the exception of the post-mitotic hub cells Drosophila melanogaster
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2.1.1.204 germarium
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 Drosophila melanogaster
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2.1.1.204 nurse cell
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 Drosophila melanogaster
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2.1.1.204 ovary
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 Drosophila melanogaster
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2.1.1.204 salivary gland cell line
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 Drosophila melanogaster
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2.1.1.204 spermatocyte
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 Drosophila melanogaster
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2.1.1.204 testis
-
 Drosophila melanogaster
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Synonyms

EC Number Synonyms Comment Organism
2.1.1.204 Dnmt2
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 Drosophila melanogaster