Literature summary extracted from

Gurovic, M.S.; Castro, M.J.; Richmond, V.; Faraoni, M.B.; Maier, M.S.; Murray, A.P.
Triterpenoids with acetylcholinesterase inhibition from Chuquiraga erinacea D. Don. subsp. erinacea (Asteraceae) (2009), Planta Med., 76, 607-610.

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
3.1.1.7	alpha-amyrin	a pentacyclic triterpene, isolated the ethanolic extract of Chuquiraga erinacea D. Don. subsp. erinacea leaves as a mixture of alpha- and beta amyrin	Homo sapiens
3.1.1.7	beta-amyrin	a pentacyclic triterpene, isolated the ethanolic extract of Chuquiraga erinacea D. Don. subsp. erinacea leaves as a mixture of alpha- and beta amyrin	Homo sapiens
3.1.1.7	calenduladiol	a pentacyclic triterpene, isolated the ethanolic extract of Chuquiraga erinacea D. Don. subsp. erinacea leaves. 31.2% inhibition at 0.5 mM	Homo sapiens
3.1.1.7	disodium calenduladiol disulfate	a semisynthetic derivative of calenduladiol, elicits higher AChE inhibition than this with 94.1% inhibition at 0.5 mM	Homo sapiens
3.1.1.7	faradiol	a pentacyclic triterpene, isolated the ethanolic extract of Chuquiraga erinacea D. Don. subsp. erinacea leaves	Homo sapiens
3.1.1.7	heliantriol B2	a pentacyclic triterpene, isolated the ethanolic extract of Chuquiraga erinacea D. Don. subsp. erinacea leaves	Homo sapiens
3.1.1.7	lupeol	a pentacyclic triterpene, isolated the ethanolic extract of Chuquiraga erinacea D. Don. subsp. erinacea leaves	Homo sapiens
3.1.1.7	additional information	no inhibition by pseudotaraxasterol and taraxasterol from the ethanolic extract of Chuquiraga erinacea D. Don. subsp. erinacea leaves	Homo sapiens

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.1.1.7	Homo sapiens	-	-	-

Synonyms

EC Number	Synonyms	Comment	Organism
3.1.1.7	AChE	-	Homo sapiens

IC50 Value

EC Number	IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
3.1.1.7	0.19	-	-	Homo sapiens	disodium calenduladiol disulfate

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Release 2023.1 (January 2023)