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Literature summary extracted from

  • Sandra, D.; Radha, M.; Harishkumar, M.; Yuichi, N.; Sayuri, O.; Masugi, M.
    Downregulation of urokinase-type plasminogen activator and plasminogen activator inhibitor-1 by grape seed proanthocyanidin extract (2010), Phytomedicine, 17, 42-46.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.73 plasminogen activator inhibitor-1 i.e. PAI-1 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.73 plasminogen + H2O Homo sapiens
-
 plasmin + ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.73 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.73 cell culture
-
 Homo sapiens
-
3.4.21.73 fibroblast
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.73 plasminogen + H2O
-
 Homo sapiens plasmin + ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.73 uPA
-
 Homo sapiens
3.4.21.73 Urokinase plasminogen activator
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
3.4.21.73 Homo sapiens uPA and its endogenous inhibitor PAI-1 are downregulated by grape seed, Vitis ssp., proanthocyanidin extract, both at the RNA and protein levels, due to the extract's antioxidant activity down

General Information

EC Number General Information Comment Organism
3.4.21.73 physiological function the urokinase plasminogen activator, uPA, system, comprising of uPA, its receptor uPAR and inhibitor, type 1 plasminogen activator inhibitor, PAI-1, plays a vital role in various biological processes involving extracellular proteolysis, fibrinolysis, cell migration and proliferation Homo sapiens