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Literature summary extracted from

  • Jin, L.; Zheng, Y.
    Inhibitory effects of validamycin compounds on the termites trehalase (2009), Pestic. Biochem. Physiol., 95, 28-32.
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.2.1.28 validamycin A competitive Termitoidae
3.2.1.28 validamycin B
-
 Termitoidae
3.2.1.28 validoxylamine A
-
 Termitoidae
3.2.1.28 validoxylamine B
-
 Termitoidae

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.2.1.28 additional information
-
 additional information kinetics Termitoidae
3.2.1.28 0.031
-
 trehalose pH 3.3, 37°C Termitoidae

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.2.1.28 trehalose + H2O Termitoidae
-
 2 D-glucose
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.2.1.28 Termitoidae
-
 termites
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.2.1.28 trehalose + H2O
-
 Termitoidae 2 D-glucose
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.2.1.28 trehalase
-
 Termitoidae

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.2.1.28 37
-
-
 Termitoidae

Temperature Range [°C]

EC Number Temperature Minimum [°C] Temperature Maximum [°C] Comment Organism
3.2.1.28 25 60 40% of maximal activity at 25°C and 60°C Termitoidae

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.2.1.28 3.3
-
-
 Termitoidae

pH Range

EC Number pH Minimum pH Maximum Comment Organism
3.2.1.28 3 4.5 activity range Termitoidae

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.2.1.28 0.0032
-
 validoxylamine A pH 3.3, 37°C, versus trehalose Termitoidae
3.2.1.28 0.0103
-
 validoxylamine B pH 3.3, 37°C, versus trehalose Termitoidae
3.2.1.28 0.27
-
 validamycin B pH 3.3, 37°C, versus trehalose Termitoidae
3.2.1.28 0.4
-
 validamycin A pH 3.3, 37°C, versus trehalose Termitoidae

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.2.1.28 additional information
-
 the concentrations of validoxylamine A, validoxylamine B, validamycin A and validamycin B required for 50% inhibition IC50 of termites trehalase are 14.73 mg/l, 20.80 mg/l, 3.17 x 103 mg/l, and 2.24 x 103 mg/l, respectively Termitoidae additional information