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Literature summary extracted from
- Arachin derived peptides as selective angiotensin I-converting enzyme (ACE) inhibitors: structure-activity relationship (2010), Peptides, 31, 1165-1176.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.15.1 | enalapril | i.e. (2S)-1-[(2S)-2-[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]aminopropanoyl]pyrrolidine-2-carboxylic acid | Homo sapiens |  |
| 3.4.15.1 | enalapril | i.e. (2S)-1-[(2S)-2-[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]aminopropanoyl]pyrrolidine-2-carboxylic acid | Sus scrofa | |
| 3.4.15.1 | Ile-Glu-Pro | molecular docking analysis at the active site of testis ACE, overview | Homo sapiens | |
| 3.4.15.1 | Ile-Glu-Pro | - |
Sus scrofa | |
| 3.4.15.1 | Ile-Glu-Trp | - |
Homo sapiens | |
| 3.4.15.1 | Ile-Glu-Trp | - |
Sus scrofa | |
| 3.4.15.1 | Ile-Glu-Tyr | molecular docking analysis at the active site of testis ACE, overview | Homo sapiens | |
| 3.4.15.1 | Ile-Glu-Tyr | - |
Sus scrofa | |
| 3.4.15.1 | Ile-Lys-Pro | a potent competitive inhibitor, molecular docking analysis at the active site of testis ACE, overview | Homo sapiens | |
| 3.4.15.1 | Ile-Lys-Pro | - |
Sus scrofa | |
| 3.4.15.1 | Ile-Lys-Trp | molecular docking analysis at the active site of testis ACE, overview | Homo sapiens | |
| 3.4.15.1 | Ile-Lys-Trp | - |
Sus scrofa | |
| 3.4.15.1 | Ile-Lys-Tyr | molecular docking analysis at the active site of testis ACE, overview | Homo sapiens | |
| 3.4.15.1 | Ile-Lys-Tyr | - |
Sus scrofa | |
| 3.4.15.1 | lisinopril | i.e. N2-[(1S)-1-carboxy-3-phenylpropyl]-L-lysyl-L-proline, molecular docking analysis at the active site of testis ACE, PDB ID 1086, overview | Homo sapiens | |
| 3.4.15.1 | lisinopril | i.e. N2-[(1S)-1-carboxy-3-phenylpropyl]-L-lysyl-L-proline | Sus scrofa | |
| 3.4.15.1 | additional information | inhibitory potencies of tripeptides derived from arachin, the major storage globulin of peanut, Arachis hypogaea variety TMV-2, sequence analysis, overview. Active site biniding and the degree of inhibition by the peptides correlates with the coordination distance between the catalytic Zn2+ and the carbonyl oxygen of the peptide bond between the amino-terminal and middle residue | Homo sapiens | |
| 3.4.15.1 | additional information | inhibitory potencies of tripeptides derived from arachin, the major storage globulin of peanut, Arachis hypogaea variety TMV-2, sequence analysis, overview. Active site biniding and the degree of inhibition by the peptides correlates with the coordination distance between the catalytic Zn2+ and the carbonyl oxygen of the peptide bond between the amino-terminal and middle residue. In vitro stability of the peptides to gastrointestinal proteases, overview | Sus scrofa |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.15.1 | Zn2+ | catalytically important | Homo sapiens | |
| 3.4.15.1 | Zn2+ | catalytically important | Sus scrofa | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.15.1 | Homo sapiens | - |
- |
- |
| 3.4.15.1 | Sus scrofa | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.4.15.1 | kidney | - |
Sus scrofa | - |
| 3.4.15.1 | lung | - |
Sus scrofa | - |
| 3.4.15.1 | testis | germinal isozyme | Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.15.1 | hippuryl-His-Leu + H2O | colorimetric assay method | Homo sapiens | hippuric acid + His-Leu | - |
? | |
| 3.4.15.1 | hippuryl-His-Leu + H2O | colorimetric assay method | Sus scrofa | hippuric acid + His-Leu | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.4.15.1 | ACE | - |
Homo sapiens |
| 3.4.15.1 | ACE | - |
Sus scrofa |
| 3.4.15.1 | angiotensin I-converting enzyme | - |
Homo sapiens |
| 3.4.15.1 | angiotensin I-converting enzyme | - |
Sus scrofa |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 3.4.15.1 | 37 | - |
assay at | Homo sapiens |
| 3.4.15.1 | 37 | - |
assay at | Sus scrofa |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.4.15.1 | 8.2 | - |
assay at | Homo sapiens |
| 3.4.15.1 | 8.2 | - |
assay at | Sus scrofa |
Ki Value [mM]
| EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.4.15.1 | 0.0000001 | - |
lisinopril | - |
Homo sapiens | |
| 3.4.15.1 | 0.0027 | - |
Ile-Lys-Pro | - |
Homo sapiens | |
| 3.4.15.1 | 0.0072 | - |
Ile-Glu-Pro | - |
Homo sapiens | |
| 3.4.15.1 | 0.0085 | - |
Ile-Lys-Trp | - |
Homo sapiens | |
| 3.4.15.1 | 0.013 | - |
Ile-Lys-Tyr | - |
Homo sapiens | |
| 3.4.15.1 | 0.055 | - |
Ile-Glu-Trp | - |
Homo sapiens | |
| 3.4.15.1 | 0.0835 | - |
Ile-Glu-Tyr | - |
Homo sapiens | |
IC50 Value
| EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|---|
| 3.4.15.1 | 0.007 | - |
- |
Sus scrofa | Ile-Lys-Pro | |
| 3.4.15.1 | 0.018 | - |
- |
Sus scrofa | Ile-Glu-Pro | |
| 3.4.15.1 | 0.019 | - |
- |
Sus scrofa | Ile-Lys-Trp | |
| 3.4.15.1 | 0.034 | - |
- |
Sus scrofa | Ile-Lys-Tyr | |
| 3.4.15.1 | 0.104 | - |
- |
Sus scrofa | Ile-Glu-Trp | |
| 3.4.15.1 | 0.182 | - |
- |
Sus scrofa | Ile-Glu-Tyr | |
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