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Literature summary extracted from

  • Bohn, P.; Le Fur, N.; Hagues, G.; Costentin, J.; Torquet, N.; Papamicael, C.; Marsais, F.; Levacher, V.
    Rational design of central selective acetylcholinesterase inhibitors by means of a bio-oxidisable prodrug strategy (2009), Org. Biomol. Chem., 7, 2612-2618.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.1.7 1-methyl-3-(methylcarbamoyl)-1,4-dihydroquinolin-5-yl dimethylcarbamate
-
 Homo sapiens
3.1.1.7 1-methyl-3-(morpholin-4-ylcarbonyl)-1,4-dihydroquinolin-5-yl dimethylcarbamate
-
 Homo sapiens
3.1.1.7 3-(dimethylcarbamoyl)-1-methyl-1,4-dihydroquinolin-5-yl dimethylcarbamate
-
 Homo sapiens
3.1.1.7 3-(dimethylcarbamoyl)-5-[(dimethylcarbamoyl)oxy]-1-methylquinolinium
-
 Homo sapiens
3.1.1.7 5-[(dimethylcarbamoyl)oxy]-1-methyl-3-(methylcarbamoyl)quinolinium
-
 Homo sapiens
3.1.1.7 5-[(dimethylcarbamoyl)oxy]-1-methyl-3-(morpholin-4-ylcarbonyl)quinolinium
-
 Homo sapiens
3.1.1.7 5-[(dimethylcarbamoyl)oxy]-3-(ethoxycarbonyl)-1-methylquinolinium
-
 Homo sapiens
3.1.1.7 5-[(dimethylcarbamoyl)oxy]-3-(methoxycarbonyl)-1-methylquinolinium
-
 Homo sapiens
3.1.1.7 5-[(ethylcarbamoyl)oxy]-3-(methoxycarbonyl)-1-methylquinolinium
-
 Homo sapiens
3.1.1.7 7-[(dimethylcarbamoyl)oxy]-3-(ethoxycarbonyl)-1-methylquinolinium
-
 Homo sapiens
3.1.1.7 donepezil
-
 Homo sapiens
3.1.1.7 ethyl 5-[(dimethylcarbamoyl)oxy]-1-methyl-1,4-dihydroquinoline-3-carboxylate
-
 Homo sapiens
3.1.1.7 ethyl 7-[(dimethylcarbamoyl)oxy]-1-methyl-1,4-dihydroquinoline-3-carboxylate
-
 Homo sapiens
3.1.1.7 galanthamine
-
 Homo sapiens
3.1.1.7 methyl 5-[(dimethylcarbamoyl)oxy]-1-methyl-1,4-dihydroquinoline-3-carboxylate
-
 Homo sapiens
3.1.1.7 methyl 5-[(ethylcarbamoyl)oxy]-1-methyl-1,4-dihydroquinoline-3-carboxylate
-
 Homo sapiens
3.1.1.7 additional information synthesis of a set of 1,4-dihydroquinolines and their corresponding quinolinium salts as potential enzyme inhibitors, overview. All reduced forms are unable to exhibit any anticholinesterase activity, while most of the quinolinium salts display high AChE inhibitory activity with IC50 values ranging from 0.006 mM to 7 nM. Design of a bio-oxidisable prodrug for central selective AChE inhibitory activity Homo sapiens
3.1.1.7 rivastigmine
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.7 Homo sapiens
-
-
-

Synonyms

EC Number Synonyms Comment Organism
3.1.1.7 AChE
-
 Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.1.1.7 0.000007
-
-
 Homo sapiens 5-[(dimethylcarbamoyl)oxy]-3-(ethoxycarbonyl)-1-methylquinolinium
3.1.1.7 0.000015
-
-
 Homo sapiens 3-(dimethylcarbamoyl)-5-[(dimethylcarbamoyl)oxy]-1-methylquinolinium
3.1.1.7 0.000029
-
-
 Homo sapiens 5-[(dimethylcarbamoyl)oxy]-1-methyl-3-(methylcarbamoyl)quinolinium
3.1.1.7 0.00005
-
-
 Homo sapiens donepezil
3.1.1.7 0.00011
-
-
 Homo sapiens 5-[(dimethylcarbamoyl)oxy]-3-(methoxycarbonyl)-1-methylquinolinium
3.1.1.7 0.0005
-
-
 Homo sapiens 7-[(dimethylcarbamoyl)oxy]-3-(ethoxycarbonyl)-1-methylquinolinium
3.1.1.7 0.00086
-
-
 Homo sapiens 5-[(dimethylcarbamoyl)oxy]-1-methyl-3-(morpholin-4-ylcarbonyl)quinolinium
3.1.1.7 0.006
-
-
 Homo sapiens 5-[(ethylcarbamoyl)oxy]-3-(methoxycarbonyl)-1-methylquinolinium
3.1.1.7 1
-
 above Homo sapiens methyl 5-[(dimethylcarbamoyl)oxy]-1-methyl-1,4-dihydroquinoline-3-carboxylate
3.1.1.7 1
-
 above Homo sapiens methyl 5-[(ethylcarbamoyl)oxy]-1-methyl-1,4-dihydroquinoline-3-carboxylate
3.1.1.7 1
-
 above Homo sapiens ethyl 5-[(dimethylcarbamoyl)oxy]-1-methyl-1,4-dihydroquinoline-3-carboxylate
3.1.1.7 1
-
 above Homo sapiens ethyl 7-[(dimethylcarbamoyl)oxy]-1-methyl-1,4-dihydroquinoline-3-carboxylate
3.1.1.7 1
-
 above Homo sapiens 1-methyl-3-(morpholin-4-ylcarbonyl)-1,4-dihydroquinolin-5-yl dimethylcarbamate
3.1.1.7 1
-
 above Homo sapiens 3-(dimethylcarbamoyl)-1-methyl-1,4-dihydroquinolin-5-yl dimethylcarbamate
3.1.1.7 1
-
 above Homo sapiens 1-methyl-3-(methylcarbamoyl)-1,4-dihydroquinolin-5-yl dimethylcarbamate