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Literature summary extracted from

  • Kawasaki, S.; Watanabe, S.; Kimura, S.; Fujita, R.; Ochiai, J.; Sasaki, K.
    Regulation of dopamine-induced Na+ current response by small G-protein RhoB or C and phospholipase D in Aplysia neurons (2008), Neurosci. Res., 60, 147-155.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.4.4 Rho family G-proteins RhoB or C, but not RhoA, activate PLD. The activation is irreversibly blocked by Clostridium difficile toxin B, an inhibitor for all Rho family G-proteins, or Clostridium botulinum C3 exoenzyme, a specific blocker for RhoA-C, and also by the GAP domain of p50RhoGAP, kinetics, overview Aplysia kurodai

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.4.4 1-butanol
-
 Aplysia kurodai
3.1.4.4 alpha-synuclein binds to PLD and inhibits its activity, it also markedly depressed the dopamine-induced Na+ current response in vivo Aplysia kurodai
3.1.4.4 additional information either intracellular injection of alpha-synuclein or extracellular application of 1-butanol, inhibitors of PLD, significantly depress the dopamine-induced Na+ current response in neurons Aplysia kurodai

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.4 Aplysia kurodai
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.4 neuron from abdominal ganglia Aplysia kurodai
-

Synonyms

EC Number Synonyms Comment Organism
3.1.4.4 PLD
-
 Aplysia kurodai

General Information

EC Number General Information Comment Organism
3.1.4.4 physiological function PLD is activated by Rho family G-protein RhoB or C, which facilitates dopamine-induced Na+ current response in neurons, overview Aplysia kurodai