Any feedback?
Literature summary extracted from
- Urokinase-type plasminogen activator induces BV-2 microglial cell migration through activation of matrix metalloproteinase-9 (2010), Neurochem. Res., 35, 976-985.
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 3.4.21.73 | 52000 | - |
x * 52000, SDS-PAGE | Mus musculus |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.21.73 | plasminogen + H2O | Mus musculus | - |
plasmin + ? | - |
? |  |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.21.73 | Mus musculus | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.4.21.73 | brain | - |
Mus musculus | - |
| 3.4.21.73 | BV-2 cell | a murine microglial cell line | Mus musculus | - |
| 3.4.21.73 | microglia | - |
Mus musculus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.21.73 | plasminogen + H2O | - |
Mus musculus | plasmin + ? | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 3.4.21.73 | ? | x * 52000, SDS-PAGE | Mus musculus |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.4.21.73 | uPA | - |
Mus musculus |
| 3.4.21.73 | Urokinase-type plasminogen activator | - |
Mus musculus |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 3.4.21.73 | 37 | - |
assay at | Mus musculus |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.4.21.73 | 7.6 | - |
assay at | Mus musculus |
Expression
| EC Number | Organism | Comment | Expression |
|---|---|---|---|
| 3.4.21.73 | Mus musculus | uPA is induced by ATP in microglia. The expression and release of uPA is under active regulation in BV2 microglial cells | up |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 3.4.21.73 | additional information | the expression and release of uPA is under active regulation in BV2 microglial cells | Mus musculus |
| 3.4.21.73 | physiological function | urokinase-type plasminogen activator induces BV-2 microglial cell migration through activation of matrix metalloproteinase-9 | Mus musculus |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
