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Literature summary extracted from

  • Kandil, S., Brennan, L., McBean, G.J.
    Glutathione depletion causes a JNK and p38MAPK-mediated increase in expression of cystathionine-gamma-lyase and upregulation of the transsulfuration pathway in C6 glioma cells (2010), Neurochem. Int., 56, 611-619.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.4.1.1 DL-propargylglycine
-
 Homo sapiens
4.4.1.1 DL-propargylglycine
-
 Mus musculus
4.4.1.1 DL-propargylglycine
-
 Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.4.1.1 L-cystathionine + H2O Mus musculus
-
 L-homocysteine + pyruvate + NH3
-
 ?
4.4.1.1 L-cystathionine + H2O Homo sapiens
-
 L-homocysteine + pyruvate + NH3
-
 ?
4.4.1.1 L-cystathionine + H2O Rattus norvegicus
-
 L-homocysteine + pyruvate + NH3
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.4.1.1 Homo sapiens
-
-
-
4.4.1.1 Mus musculus
-
-
-
4.4.1.1 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.4.1.1 brain
-
 Rattus norvegicus
-
4.4.1.1 C6 glioma cell
-
 Rattus norvegicus
-
4.4.1.1 liver
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.4.1.1 L-cystathionine + H2O
-
 Mus musculus L-homocysteine + pyruvate + NH3
-
 ?
4.4.1.1 L-cystathionine + H2O
-
 Homo sapiens L-homocysteine + pyruvate + NH3
-
 ?
4.4.1.1 L-cystathionine + H2O
-
 Rattus norvegicus L-homocysteine + pyruvate + NH3
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.4.1.1 CTH
-
 Mus musculus
4.4.1.1 CTH
-
 Homo sapiens
4.4.1.1 CTH
-
 Rattus norvegicus
4.4.1.1 cystathionine-gamma-lyase
-
 Mus musculus
4.4.1.1 cystathionine-gamma-lyase
-
 Homo sapiens
4.4.1.1 cystathionine-gamma-lyase
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
4.4.1.1 pyridoxal 5'-phosphate
-
 Mus musculus
4.4.1.1 pyridoxal 5'-phosphate
-
 Homo sapiens
4.4.1.1 pyridoxal 5'-phosphate
-
 Rattus norvegicus

Expression

EC Number Organism Comment Expression
4.4.1.1 Homo sapiens glutathione depletion causes a JNK and p38MAPK-mediated increase in expression of cystathionine-gamma-lyase. Expression of cystathionine-gamma-lyase is 1.5fold increased following incubation of the cells with diethylmaleate for 3 h. Co-incubation of C6 cells with diethylmaleate and the JNK-inhibitor, SP600125, abolishes the increase in expression of cystathionine-gamma-lyase that is observed in the presence of diethylmaleate alone up