Literature summary extracted from

Lendeckel, U.; Kaehne, T.; Ten Have, S.; Bukowska, A.; Wolke, C.; Bogerts, B.; Keilhoff, G.; Bernstein, H.G.
Cathepsin K generates enkephalin from beta-endorphin: a new mechanism with possible relevance for schizophrenia (2009), Neurochem. Int., 54, 410-417.

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
3.4.22.38	beta-endorphin + H2O	Homo sapiens	-	Met-enkephalin + ?	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.4.22.38	Homo sapiens	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
3.4.22.38	infundibular nucleus	increased numbers of cathepsin K immunoreactive cells are found in left and right arcuate nucleus of schizophrenics	Homo sapiens	-
3.4.22.38	SH-SY5Y cell	-	Homo sapiens	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3.4.22.38	beta-endorphin + H2O	-	Homo sapiens	Met-enkephalin + ?	-	?

Expression

EC Number	Organism	Comment	Expression
3.4.22.38	Homo sapiens	cathepsin K becomes up-regulated in its cerebral expression by neuroleptic treatment	up

General Information

EC Number	General Information	Comment	Organism
3.4.22.38	physiological function	cathepsin K may significantly contribute to altered opioid levels in brains of schizophrenics	Homo sapiens

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Release 2023.1 (January 2023)