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Literature summary extracted from

  • Imig, J.D.; Hammock, B.D.
    Soluble epoxide hydrolase as a therapeutic target for cardiovascular diseases (2009), Nat. Rev. Drug Discov., 8, 794-805.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
3.3.2.10 pharmacology the enzyme is a promising therapeutic strategy for cardiovascular disease Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.3.2.10 AUDA
-
 Homo sapiens
3.3.2.10 AUDA-BE
-
 Homo sapiens
3.3.2.10 additional information sEH inhibitors are developed to enhance the cardiovascular actions of epoxyeicosatrienoic acids, treatment potentials, cardiovascular therapeutic effects, antihypertensive effects, kidney-protective properties, cardiac-protective properties, and protection against ischaemic stroke and vascular disease of sEH inhibitors, overview Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.3.2.10 soluble
-
 Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.3.2.10 (5Z,11Z,14Z)-8,9-epoxyeicosatrienoic acid + H2O Homo sapiens
-
 (5Z,11Z,14Z)-8,9-dihydroxyeicosatrienoic acid
-
 ?
3.3.2.10 (5Z,8Z,11Z)-14,15-epoxyeicosatrienoic acid + H2O Homo sapiens
-
 (5Z,8Z,11Z)-14,15-dihydroxyeicosatrienoic acid
-
 ?
3.3.2.10 (5Z,8Z,14Z)-11,12-epoxyeicosatrienoic acid + H2O Homo sapiens
-
 (5Z,8Z,14Z)-11,12-dihydroxyeicosatrienoic acid
-
 ?
3.3.2.10 (8Z,11Z,14Z)-5,6-epoxyeicosatrienoic acid + H2O Homo sapiens
-
 (8Z,11Z,14Z)-5,6-dihydroxyeicosatrienoic acid
-
 ?
3.3.2.10 additional information Homo sapiens Vascular actions and antiinflammatory actions of epoxyeicosatrienoic acids, overview ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.3.2.10 Homo sapiens P34913
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.3.2.10 brain
-
 Homo sapiens
-
3.3.2.10 heart
-
 Homo sapiens
-
3.3.2.10 kidney
-
 Homo sapiens
-
3.3.2.10 liver
-
 Homo sapiens
-
3.3.2.10 lung
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.3.2.10 (5Z,11Z,14Z)-8,9-epoxyeicosatrienoic acid + H2O
-
 Homo sapiens (5Z,11Z,14Z)-8,9-dihydroxyeicosatrienoic acid
-
 ?
3.3.2.10 (5Z,8Z,11Z)-14,15-epoxyeicosatrienoic acid + H2O
-
 Homo sapiens (5Z,8Z,11Z)-14,15-dihydroxyeicosatrienoic acid
-
 ?
3.3.2.10 (5Z,8Z,14Z)-11,12-epoxyeicosatrienoic acid + H2O
-
 Homo sapiens (5Z,8Z,14Z)-11,12-dihydroxyeicosatrienoic acid
-
 ?
3.3.2.10 (8Z,11Z,14Z)-5,6-epoxyeicosatrienoic acid + H2O
-
 Homo sapiens (8Z,11Z,14Z)-5,6-dihydroxyeicosatrienoic acid
-
 ?
3.3.2.10 additional information Vascular actions and antiinflammatory actions of epoxyeicosatrienoic acids, overview Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.3.2.10 SEH
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
3.3.2.10 metabolism the enzyme is involved in the arachidonate cascade, pathways overview Homo sapiens
3.3.2.10 physiological function conversion of epoxyeicosatrienoic acids to their corresponding diols, dihydroxyeicosatrienoic acids, DHETS, by sEH is responsible for decreasing EET levels and thereby diminishing their beneficial cardiovascular properties, detailed overview Homo sapiens