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Literature summary extracted from

  • Lemaire, G.; Guittet, O.; Vesin, M.; Lepoivre, M.; Cottet, M.
    Glutathione depletion reveals impairment of antigen processing and inhibition of cathepsin activity by nitric oxide in antigen-presenting cells (2009), Mol. Immunol., 46, 1100-1108.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.22.1 interferon-gamma
-
 Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.22.1 CA-074-Me
-
 Mus musculus
3.4.22.1 lipopolysaccharides
-
 Mus musculus
3.4.22.1 NO
-
 Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.22.1 extracellular RAW-264.7 cell culture supernatant Mus musculus
-
-
3.4.22.1 lysosome
-
 Mus musculus 5764
-

Organism

EC Number Organism UniProt Comment Textmining
3.4.22.1 Mus musculus
-
 Balb/c mice
-
3.4.22.1 Mus musculus BALB/c
-
 Balb/c mice
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.22.1 A20 cell B cell line Mus musculus
-
3.4.22.1 B-cell lymphoma cell
-
 Mus musculus
-
3.4.22.1 B-lymphocyte
-
 Mus musculus
-
3.4.22.1 RAW-264.7 cell
-
 Mus musculus
-
3.4.22.1 T-lymphocyte
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.22.1 N-benzyloxycarbonyl-Arg-Arg-4-methylcoumarin 7-amide + H2O
-
 Mus musculus N-benzyloxycarbonyl-Arg-Arg + 7-amino-4-methylcoumarin
-
 ?
3.4.22.1 N-benzyloxycarbonyl-Arg-Arg-4-methylcoumarin 7-amide + H2O
-
 Mus musculus BALB/c N-benzyloxycarbonyl-Arg-Arg + 7-amino-4-methylcoumarin
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.22.1 cat B
-
 Mus musculus

General Information

EC Number General Information Comment Organism
3.4.22.1 malfunction exposure of GSH-depleted B cells to NO-releasing compounds lowers their capacity to present a reduced and alkylated lysozyme due to inhibition of cathepsin B by NO, overview. Cells with a normal GSH content are protected from this inhibition Mus musculus
3.4.22.1 physiological function cathepsin B activity is necessary for TAP-HEL, a reduced and alkylated lysozyme, processing, it is essential for generation of the HEL-derived antigenic peptide recognized by B9.1 cells Mus musculus