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Literature summary extracted from
- Identification and characterization of a putative basic helix-loop-helix (bHLH) transcription factor interacting with calcineurin in C. elegans (2009), Mol. Cells, 28, 455-461.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.1.3.16 | Calmodulin | calcineurin is a Ca2+/calmodulin-activated Ser/Thr phosphatase | Caenorhabditis elegans |  |
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 3.1.3.16 | co-expression of cacineurin with HLH-11 and interaction analysis using the yeast two-hybrid system | Caenorhabditis elegans |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.1.3.16 | Ca2+ | calcineurin is a Ca2+/calmodulin-activated Ser/Thr phosphatase | Caenorhabditis elegans | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.1.3.16 | Caenorhabditis elegans | - |
subunits A and B are encoded by genes tax-6 and cnb-1 | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.1.3.16 | additional information | HLH-11, a member of basic helix-loop-helix proteins, binds to calcineurin catalytic subunit Tax-6, probably regulating TAX-6 as a transcription factor and/or a functional regulator. HLH-11 is involved in regulation of many developmental processes such as cell proliferation and differentiation, sex determination and myogenesis, HLH-11 deletion phenotype, overview | Caenorhabditis elegans | ? | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 3.1.3.16 | heterodimer | - |
Caenorhabditis elegans |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.1.3.16 | calcineurin | - |
Caenorhabditis elegans |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 3.1.3.16 | physiological function | calcineurin play roles in various signaling pathways such as fertility, movement, body size regulation and serotonin-mediated egg laying | Caenorhabditis elegans |
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