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Literature summary extracted from

  • Yoon, S.H.; Min, d.o..S.; Bae, Y.S.
    Over-expression of phospholipase D isozymes down-regulates protein kinase CKII activity via proteasome-dependent CKIIbeta degradation in NIH3T3 cells (2009), Mol. Cells, 27, 299-305.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.4.4 overexpression of isozymes PLD1 and PLD2 in NIH3T3 cells Mus musculus

Protein Variants

EC Number Protein Variants Comment Organism
3.1.4.4 K758R catalytically inactive mutant of PLD2 Mus musculus
3.1.4.4 K898R catalytically inactive mutant of PLD1 Mus musculus
3.1.4.4 additional information overexpression of phospholipase D isozymes, leads to downregulation of protein kinase CKII activity via proteasome-dependent CKIIbeta degradation in NIH3T3 cells. Co-localization of CKIIbeta and PLD isozymes in NIH3T3 cells Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.4.4 1-butanol inhibits PLD hydrolytic activity Mus musculus
3.1.4.4 additional information no inhibition by 2-butanol Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.4.4 additional information Mus musculus PLD also performs transphosphatidylation using 1-butanol as phosphatidyl acceptor ?
-
?

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.4 Mus musculus
-
isozymes PLD1 and PLD2
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.1.4.4 additional information
-
PLD transphosphatidylation activity, overview Mus musculus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.4 additional information PLD also performs transphosphatidylation using 1-butanol as phosphatidyl acceptor Mus musculus ?
-
?
3.1.4.4 additional information the catalytic activity of PLD is not required for PLD-mediated CKII inhibition, possible inhibition mechanism, overview Mus musculus ?
-
?

Synonyms

EC Number Synonyms Comment Organism
3.1.4.4 PLD
-
Mus musculus