Literature summary extracted from
Yoon, S.H.; Min, d.o..S.; Bae, Y.S.
Over-expression of phospholipase D isozymes down-regulates protein kinase CKII activity via proteasome-dependent CKIIbeta degradation in NIH3T3 cells (2009), Mol. Cells, 27, 299-305.
Cloned(Commentary)
EC Number |
Cloned (Comment) |
Organism |
---|
3.1.4.4 |
overexpression of isozymes PLD1 and PLD2 in NIH3T3 cells |
Mus musculus |
Protein Variants
EC Number |
Protein Variants |
Comment |
Organism |
---|
3.1.4.4 |
K758R |
catalytically inactive mutant of PLD2 |
Mus musculus |
3.1.4.4 |
K898R |
catalytically inactive mutant of PLD1 |
Mus musculus |
3.1.4.4 |
additional information |
overexpression of phospholipase D isozymes, leads to downregulation of protein kinase CKII activity via proteasome-dependent CKIIbeta degradation in NIH3T3 cells. Co-localization of CKIIbeta and PLD isozymes in NIH3T3 cells |
Mus musculus |
Inhibitors
EC Number |
Inhibitors |
Comment |
Organism |
Structure |
---|
3.1.4.4 |
1-butanol |
inhibits PLD hydrolytic activity |
Mus musculus |
|
3.1.4.4 |
additional information |
no inhibition by 2-butanol |
Mus musculus |
|
Natural Substrates/ Products (Substrates)
EC Number |
Natural Substrates |
Organism |
Comment (Nat. Sub.) |
Natural Products |
Comment (Nat. Pro.) |
Rev. |
Reac. |
---|
3.1.4.4 |
additional information |
Mus musculus |
PLD also performs transphosphatidylation using 1-butanol as phosphatidyl acceptor |
? |
- |
? |
|
Organism
EC Number |
Organism |
UniProt |
Comment |
Textmining |
---|
3.1.4.4 |
Mus musculus |
- |
isozymes PLD1 and PLD2 |
- |
Specific Activity [micromol/min/mg]
EC Number |
Specific Activity Minimum [µmol/min/mg] |
Specific Activity Maximum [µmol/min/mg] |
Comment |
Organism |
---|
3.1.4.4 |
additional information |
- |
PLD transphosphatidylation activity, overview |
Mus musculus |
Substrates and Products (Substrate)
EC Number |
Substrates |
Comment Substrates |
Organism |
Products |
Comment (Products) |
Rev. |
Reac. |
---|
3.1.4.4 |
additional information |
PLD also performs transphosphatidylation using 1-butanol as phosphatidyl acceptor |
Mus musculus |
? |
- |
? |
|
3.1.4.4 |
additional information |
the catalytic activity of PLD is not required for PLD-mediated CKII inhibition, possible inhibition mechanism, overview |
Mus musculus |
? |
- |
? |
|
Synonyms
EC Number |
Synonyms |
Comment |
Organism |
---|
3.1.4.4 |
PLD |
- |
Mus musculus |