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Literature summary extracted from

  • Soza, S.; Leva, V.; Vago, R.; Ferrari, G.; Mazzini, G.; Biamonti, G.; Montecucco, A.
    DNA ligase I deficiency leads to replication-dependent DNA damage and impacts cell morphology without blocking cell cycle progression (2009), Mol. Cell. Biol., 29, 2032-2041.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6.5.1.1 ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m Homo sapiens
-
 AMP + diphosphate + (deoxyribonucleotide)n+m
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
6.5.1.1 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.5.1.1 46BR.1G1 cell the cell line is characterized by drastically reduced replicative DNA ligase I activity Homo sapiens
-
6.5.1.1 MRC-5V1 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.5.1.1 ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m
-
 Homo sapiens AMP + diphosphate + (deoxyribonucleotide)n+m
-
 ?

Synonyms

EC Number Synonyms Comment Organism
6.5.1.1 ATP-dependent DNA ligase I
-
 Homo sapiens
6.5.1.1 LigI
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
6.5.1.1 ATP
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
6.5.1.1 malfunction DNA ligase I deficiency leads to replication-dependent DNA damage and impacts cell morphology without blocking cell cycle progression. LigI deficiency affects the maturation of nascent DNA and increases the frequency of gammaH2AX foci throughout the cell cycle. LigI deficiency leads to chronic activation of the ataxia telangiectasia mutated-mediated DNA damage checkpoint Homo sapiens