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Literature summary extracted from

  • Steinhour, E.; Sherwani, S.I.; Mazerik, J.N.; Ciapala, V.; O'Connor Butler, E.; Cruff, J.P.; Magalang, U.; Parthasarathy, S.; Sen, C.K.; Marsh, C.B.; Kuppusamy, P.; Parinandi, N.L.
    Redox-active antioxidant modulation of lipid signaling in vascular endothelial cells: vitamin C induces activation of phospholipase D through phospholipase A2, lipoxygenase, and cyclooxygenase (2008), Mol. Cell. Biochem., 315, 97-112.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.4.4 L-ascorbic acid activates the lipid signaling enzyme PLD at pharmacological doses, 5 mM, in the bovine lung microvascular endothelial cells, with modulation of PLD activation by phospholipase A2, PLA2. Antioxidants attenuate vitamin C-induced PLA2 , e.g. N-acetylcysteine, propyl gallate, or enzyme catalase activation Bos taurus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.4.4 additional information Bos taurus PLD also performs transphosphatidylation using 1-butanol as phosphatidyl acceptor, the transphosphatidylation reaction is an index of PLD activity in intact cells ?
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Organism

EC Number Organism UniProt Comment Textmining
3.1.4.4 Bos taurus
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.4 lung microvascular endothelial cells Bos taurus
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3.1.4.4 vascular endothelial cell
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Bos taurus
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Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.1.4.4 additional information
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PLD transphosphatidylation activity at different conditions, overview Bos taurus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.4 additional information PLD also performs transphosphatidylation using 1-butanol as phosphatidyl acceptor, the transphosphatidylation reaction is an index of PLD activity in intact cells Bos taurus ?
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?

Synonyms

EC Number Synonyms Comment Organism
3.1.4.4 PLD
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Bos taurus