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Literature summary extracted from

  • Sharbaugh, D.M.; Talham, D.R.
    Effect of phospholipase A2 hydrolysis products on calcium oxalate precipitation at lipid interfaces (2010), Langmuir, 26, 4925-4932.
    View publication on PubMed

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.4 Naja mossambica
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-
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.4 venom
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 Naja mossambica
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.4 1,2-dipalmitoyl-phosphatidylcholine + H2O hydrolyzes the sn-2 position of a phospholipid liberating a fatty acid and a lysolipid Naja mossambica 1-palmitoyl-glycerophosphorylcholine + palmitic acid
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 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.1.4 phospholipase A2
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 Naja mossambica
3.1.1.4 PLA2
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 Naja mossambica

General Information

EC Number General Information Comment Organism
3.1.1.4 metabolism hydrolyzes dipalmitoylphosphatidylcholine monolayers in the presence of a supersaturated calcium oxalate subphase, inducing the rapid and plentiful nucleation of calcium oxalate at the lipid interface. Calcium oxalate crystal growth at a ternary monolayer of dipalmitoylphosphatidylcholine, palmitic acid, and a 22-carbon chain lysophospholipid dramatically increases relative to monolayers of just dipalmitoylphosphatidylcholine Naja mossambica
3.1.1.4 physiological function possible link between increased phospholipase activity, which is associated with hyperoxaluria, and calcium oxalate precipitation Naja mossambica