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Literature summary extracted from

  • Costantini, T.W.; Loomis, W.H.; Putnam, J.G.; Kroll, L.; Eliceiri, B.P.; Baird, A.; Bansal, V.; Coimbra, R.
    Pentoxifylline modulates intestinal tight junction signaling after burn injury: effects on myosin light chain kinase (2009), J. Trauma, 66, 17-24.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.18 additional information treatment with pentoxifylline attenuates activation of MLCK likely through its ability to decrease local tumor necrosis factor-alpha synthesis and nucleat factor kappaB activation after burn Mus musculus
2.7.11.18 tumor necrosis factor-alpha
-
 Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.18 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.18 small intestine
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.18 ATP + myosin light chain
-
 Mus musculus ADP + myosin light chain phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.18 MLCK
-
 Mus musculus
2.7.11.18 myosin light chain kinase
-
 Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.18 ATP
-
 Mus musculus

Expression

EC Number Organism Comment Expression
2.7.11.18 Mus musculus severe burn injury increases intestinal MLCK protein levels 3.6fold after 2h in animals resuscitated with normal saline up