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Literature summary extracted from

  • Willemse, J.L.; Heylen, E.; Nesheim, M.E.; Hendriks, D.F.
    Carboxypeptidase U (TAFIa): a new drug target for fibrinolytic therapy? (2009), J. Thromb. Haemost., 7, 1962-1971.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.17.20 plasmin
-
 Homo sapiens
3.4.17.20 thrombin
-
 Homo sapiens
3.4.17.20 thrombin-thrombomodulin
-
 Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.17.20 2-(3-carbamimidamidophenyl)-3-sulfanylpropanoic acid
-
 Homo sapiens
3.4.17.20 3-(6-aminopyridin-3-yl)-2-[1-(3-methylbutyl)-1H-imidazol-4-yl]propanoic acid
-
 Homo sapiens
3.4.17.20 AZD-9684
-
 Homo sapiens
3.4.17.20 BX 528
-
 Homo sapiens
3.4.17.20 DL-2-mercapto methyl-3-guanidinoethyl-thiopropanoic acid
-
 Homo sapiens
3.4.17.20 EF6265
-
 Homo sapiens
3.4.17.20 epsilon-amino caproic acid
-
 Homo sapiens
3.4.17.20 guanidinoethyl-mercaptosuccinic acid
-
 Homo sapiens
3.4.17.20 leech carboxypeptidase inhibitor
-
 Homo sapiens
3.4.17.20 potato tuber carboxypeptidase inhibitor competitive inhibition in the nanomolar range Homo sapiens
3.4.17.20 SAR-104772
-
 Homo sapiens
3.4.17.20 tick carboxypeptidase inhibitor
-
 Homo sapiens
3.4.17.20 UK-396082
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.17.20 fibrin + H2O Homo sapiens
-
 fibrin + L-Lys
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.17.20 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.17.20 blood plasma
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.17.20 fibrin + H2O
-
 Homo sapiens fibrin + L-Lys
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.17.20 CPU
-
 Homo sapiens
3.4.17.20 TAFIa
-
 Homo sapiens
3.4.17.20 thrombin-activatable fibrinolysis inhibitor
-
 Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.4.17.20 0.000002
-
-
 Homo sapiens 3-(6-aminopyridin-3-yl)-2-[1-(3-methylbutyl)-1H-imidazol-4-yl]propanoic acid
3.4.17.20 0.000003
-
-
 Homo sapiens 2-(3-carbamimidamidophenyl)-3-sulfanylpropanoic acid