Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Bernstein, H.G.; Ernst, T.; Lendeckel, U.; Bukowska, A.; Ansorge, S.; Stauch, R.; Have, S.T.; Steiner, J.; Dobrowolny, H.; Bogerts, B.
    Reduced neuronal expression of insulin-degrading enzyme in the dorsolateral prefrontal cortex of patients with haloperidol-treated, chronic schizophrenia (2009), J. Psychiatr. Res., 43, 1095-1105.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.24.56 the gene encoding IDE is located on chromosome 10q23-q25, a gene locus linked to schizophrenia Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.24.56 Zn2+ metallopeptidase Homo sapiens
3.4.24.56 Zn2+ metallopeptidase Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.24.56 beta-endorphin + H2O Homo sapiens
-
 gamma-endorphin + ?
-
 ?
3.4.24.56 beta-endorphin + H2O Rattus norvegicus
-
 gamma-endorphin + ?
-
 ?
3.4.24.56 Glucagon + H2O Homo sapiens
-
 ?
-
 ?
3.4.24.56 Glucagon + H2O Rattus norvegicus
-
 ?
-
 ?
3.4.24.56 insulin + H2O Homo sapiens high specificity insulin peptide fragments
-
 ?
3.4.24.56 insulin + H2O Rattus norvegicus high specificity insulin peptide fragments
-
 ?
3.4.24.56 insulin-like growth factor I + H2O Homo sapiens
-
 insulin-like growth factor I peptide fragments
-
 ?
3.4.24.56 insulin-like growth factor I + H2O Rattus norvegicus
-
 insulin-like growth factor I peptide fragments
-
 ?
3.4.24.56 insulin-like growth factor II + H2O Homo sapiens
-
 insulin-like growth factor II peptide fragments
-
 ?
3.4.24.56 insulin-like growth factor II + H2O Rattus norvegicus
-
 insulin-like growth factor II peptide fragments
-
 ?
3.4.24.56 additional information Homo sapiens IDE is a neutral thiol metalloprotease ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.56 Homo sapiens
-
-
-
3.4.24.56 Rattus norvegicus
-
 male Wistar rats
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.24.56 brain left and right dorsolateral prefrontal cortex, expression of IDE protein in postmortem brains of healthy subjects and patients with schizophrenia, immunohistochemic analysis, overview Homo sapiens
-
3.4.24.56 brain left and right dorsolateral prefrontal cortex, immunohistochemic IDE expression analysis, overview Rattus norvegicus
-
3.4.24.56 hypothalamus
-
 Rattus norvegicus
-
3.4.24.56 hypothalamus high IDE content Homo sapiens
-
3.4.24.56 neuron
-
 Homo sapiens
-
3.4.24.56 neuron
-
 Rattus norvegicus
-
3.4.24.56 SH-SY5Y cell a neuroblastoma cell line Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.56 beta-endorphin + H2O
-
 Homo sapiens gamma-endorphin + ?
-
 ?
3.4.24.56 beta-endorphin + H2O
-
 Rattus norvegicus gamma-endorphin + ?
-
 ?
3.4.24.56 Glucagon + H2O
-
 Homo sapiens ?
-
 ?
3.4.24.56 Glucagon + H2O
-
 Rattus norvegicus ?
-
 ?
3.4.24.56 insulin + H2O high specificity Homo sapiens insulin peptide fragments
-
 ?
3.4.24.56 insulin + H2O high specificity Rattus norvegicus insulin peptide fragments
-
 ?
3.4.24.56 insulin-like growth factor I + H2O
-
 Homo sapiens insulin-like growth factor I peptide fragments
-
 ?
3.4.24.56 insulin-like growth factor I + H2O
-
 Rattus norvegicus insulin-like growth factor I peptide fragments
-
 ?
3.4.24.56 insulin-like growth factor II + H2O
-
 Homo sapiens insulin-like growth factor II peptide fragments
-
 ?
3.4.24.56 insulin-like growth factor II + H2O
-
 Rattus norvegicus insulin-like growth factor II peptide fragments
-
 ?
3.4.24.56 additional information IDE is a neutral thiol metalloprotease Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.24.56 IDE
-
 Homo sapiens
3.4.24.56 IDE
-
 Rattus norvegicus
3.4.24.56 Insulin-degrading enzyme
-
 Homo sapiens
3.4.24.56 Insulin-degrading enzyme
-
 Rattus norvegicus
3.4.24.56 Insulinase
-
 Homo sapiens
3.4.24.56 Insulinase
-
 Rattus norvegicus

Expression

EC Number Organism Comment Expression
3.4.24.56 Homo sapiens reduced neuronal expression of insulin-degrading enzyme in the dorsolateral prefrontal cortex of patients with haloperidol-treated, chronic schizophrenia down
3.4.24.56 Rattus norvegicus reduced neuronal expression of insulin-degrading enzyme in the left and right dorsolateral prefrontal cortex, but not in other brain areas investigated, of haloperidol-treated rats down

General Information

EC Number General Information Comment Organism
3.4.24.56 malfunction reduced neuronal expression of insulin-degrading enzyme in the left and right dorsolateral prefrontal cortex, but not in other brain areas investigated, of haloperidol-treated patients or patients with chronic schizophrenia. Reduced cortical IDE expression might be part of the disturbed insulin signaling cascades found in schizophrenia. Furthermore, it might contribute to the altered metabolism of certain neuropeptides, IGF-I and IGF-II, betab-endorphin, in schizophrenia Homo sapiens
3.4.24.56 malfunction reduced neuronal expression of insulin-degrading enzyme in the left and right dorsolateral prefrontal cortex, but not in other brain areas investigated, of haloperidol-treated rats Rattus norvegicus