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Literature summary extracted from

  • Werthmann, R.C.; von Hayn, K.; Nikolaev, V.O.; Lohse, M.J.; Buenemann, M.
    Real-time monitoring of cAMP levels in living endothelial cells: thrombin transiently inhibits adenylyl cyclase 6 (2009), J. Physiol., 587, 4091-4104.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
4.6.1.1 forskolin
-
 Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.6.1.1 Ca2+ isoforms AC5 and AC6 are inhibited by Ca2+ Homo sapiens
4.6.1.1 thrombin thrombin transiently inhibits adenylyl cyclase 6 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.6.1.1 ATP Homo sapiens
-
 3',5'-cyclic-AMP + diphosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.5 Homo sapiens
-
-
-
4.6.1.1 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.5 blood plasma
-
 Homo sapiens
-
4.6.1.1 umbilical vein endothelial cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.6.1.1 ATP
-
 Homo sapiens 3',5'-cyclic-AMP + diphosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.6.1.1 AC5 isoform Homo sapiens
4.6.1.1 AC6 isoform Homo sapiens
4.6.1.1 adenylyl cyclase
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
3.4.21.5 physiological function thrombin transiently inhibits adenylyl cyclase 6, the Ca2+-elevating agent thrombin increases endothelial permeability and decreases cAMP levels Homo sapiens