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Literature summary extracted from

  • Takai, S.; Jin, D.; Ohzu, M.; Tanaka, K.; Miyazaki, M.
    Chymase inhibition provides pancreatic islet protection in hamsters with streptozotocin-induced diabetes (2009), J. Pharmacol. Sci., 110, 459-465.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.39 TY-51469 i.e. 2-[4-(5-fluoro-3-methylbenzo[b]thiophen-2-yl)sulfonamido-3-methanesulfonylphenyl]thiazole-4-carboxylic acid, TY-51469 has a high specificity for chymase Mesocricetus auratus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.39 angiotensin I + H2O Mesocricetus auratus
-
 angiotensin II + ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.39 Mesocricetus auratus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.39 pancreas
-
 Mesocricetus auratus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.39 angiotensin I + H2O
-
 Mesocricetus auratus angiotensin II + ?
-
 ?
3.4.21.39 succinyl-L-Ala-L-Ala-L-Pro-L-Phe-7-amido-4-methylcoumarin + H2O
-
 Mesocricetus auratus succinyl-L-Ala-L-Ala-L-Pro-L-Phe + 7-amino-4-methylcoumarin
-
 ?

General Information

EC Number General Information Comment Organism
3.4.21.39 malfunction chymase inhibition protects against pancreatic islet disorganization Mesocricetus auratus