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Literature summary extracted from

  • Mizoguchi, H.; Takuma, K.; Fukuzaki, E.; Ibi, D.; Someya, E.; Akazawa, K.H.; Alkam, T.; Tsunekawa, H.; Mouri, A.; Noda, Y.; Nabeshima, T.; Yamada, K.
    Matrix metalloprotease-9 inhibition improves amyloid beta-mediated cognitive impairment and neurotoxicity in mice (2009), J. Pharmacol. Exp. Ther., 331, 14-22.
    View publication on PubMed

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.24.35 105000
-
 the molecular mass of recombinant MMP-9 is approximately 105000 Da, SDS-PAGE Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.24.35 chondroitin sulfate proteoglycan + H2O Mus musculus
-
 ?
-
 ?
3.4.24.35 collagen type IV + H2O Mus musculus
-
 ?
-
 ?
3.4.24.35 collagen type V + H2O Mus musculus
-
 ?
-
 ?
3.4.24.35 Laminin + H2O Mus musculus
-
 ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.35 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.24.35 hippocampus
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.35 chondroitin sulfate proteoglycan + H2O
-
 Mus musculus ?
-
 ?
3.4.24.35 collagen type IV + H2O
-
 Mus musculus ?
-
 ?
3.4.24.35 collagen type V + H2O
-
 Mus musculus ?
-
 ?
3.4.24.35 Gelatin + H2O
-
 Mus musculus ?
-
 ?
3.4.24.35 Laminin + H2O
-
 Mus musculus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.24.35 matrix metalloproteinase-9
-
 Mus musculus
3.4.24.35 MMP-9
-
 Mus musculus

Expression

EC Number Organism Comment Expression
3.4.24.35 Mus musculus the intracerebroventricular injection of amyloid beta25-35, amyloid beta1-40, and amyloid beta1-42, but not amyloid beta40-1, transiently increases MMP-9 activity and protein expression in the hippocampus, the expression of MMP-9 is increased in both neurons and glial cells in the hippocampus after amyloid beta treatment up

General Information

EC Number General Information Comment Organism
3.4.24.35 malfunction matrix metalloprotease-9 inhibition improves amyloid beta-mediated cognitive impairment and neurotoxicity in mice Mus musculus
3.4.24.35 physiological function MMP-9 plays a causal role in amyloid beta-induced cognitive impairment and neurotoxicity Mus musculus