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Literature summary extracted from

  • Helgager, J.; Li, J.; Lubensky, I.A.; Lonser, R.; Zhuang, Z.
    Troglitazone reduces glyoxalase I protein expression in glioma and potentiates the effects of chemotherapeutic agents (2010), J. Oncol., 2010, 373491.
    View publication on PubMedView publication on EuropePMC

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
4.4.1.5 23000
-
 SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.4.1.5 methylglyoxal + glutathione Homo sapiens
-
 (R)-S-lactoylglutathione
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.4.1.5 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.4.1.5 A-172 cell
-
 Homo sapiens
-
4.4.1.5 glioma cell
-
 Homo sapiens
-
4.4.1.5 U-251 cell
-
 Homo sapiens
-
4.4.1.5 U-373MG cell
-
 Homo sapiens
-
4.4.1.5 U-87MG cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.4.1.5 methylglyoxal + glutathione
-
 Homo sapiens (R)-S-lactoylglutathione
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.4.1.5 GLO-1
-
 Homo sapiens
4.4.1.5 glyoxalase I
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
4.4.1.5 glutathione
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
4.4.1.5 Homo sapiens troglitazone treatment (0.025-0.1 mM) reduces glyoxalase I protein expression in glioma down