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Literature summary extracted from

  • Everett, P.B.; Senogles, S.E.
    D3 dopamine receptor signals to activation of phospholipase D through a complex with Rho (2010), J. Neurochem., 112, 963-971.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.4.4 4beta-phorbol-12,13-didecanoate i.e. 4betaPDD, a phorbol ester Homo sapiens
3.1.4.4 ionomycin a Ca2+ ionophore Homo sapiens
3.1.4.4 R(+)-hydroxy(dipropylamino)tetralin hydrobromide i.e. (+)7-OH DPAT, stimulates D3 receptor-mediated PLD activity Homo sapiens
3.1.4.4 RhoA protein recombinant D3 dopamine receptor, D2S receptor, signals to activation of phospholipase D through a complex with RhoA in HEK-293 cells Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.4.4 phosphatidylcholine + H2O Homo sapiens
-
 choline + phosphatidic acid
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.4 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.4 HEK-293 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.4 phosphatidylcholine + ethanol PLD also performs transphosphatidylation using ethanol as phosphatidyl acceptor Homo sapiens choline + phosphatidyl ethanol
-
 ?
3.1.4.4 phosphatidylcholine + H2O
-
 Homo sapiens choline + phosphatidic acid
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.4.4 PLD
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.1.4.4 37
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.4.4 7.4
-
 assay at Homo sapiens