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Literature summary extracted from

  • Liu, W.; Hendren, J.; Qin, X.J.; Shen, J.; Liu, K.J.
    Normobaric hyperoxia attenuates early blood-brain barrier disruption by inhibiting MMP-9-mediated occludin degradation in focal cerebral ischemia (2009), J. Neurochem., 108, 811-820.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.24.35 BB1101 MMP inhibitor Rattus norvegicus
3.4.24.35 GM6001 MMP inhibitor, complete inhibition at 0.025 mM Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.35 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.24.35 brain
-
 Rattus norvegicus
-
3.4.24.35 microvessel
-
 Rattus norvegicus
-
3.4.24.35 telencephalon
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.35 Gelatin + H2O
-
 Rattus norvegicus ?
-
 ?
3.4.24.35 occludin + H2O
-
 Rattus norvegicus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.24.35 matrix metalloproteinase-9
-
 Rattus norvegicus
3.4.24.35 MMP-9
-
 Rattus norvegicus

Expression

EC Number Organism Comment Expression
3.4.24.35 Rattus norvegicus normobaric hyperoxia inhibits MMP-9-mediated occludin degradation in the ischemic hemispheric microvessels down
3.4.24.35 Rattus norvegicus ischemia and reperfusion induce an upregulation of MMP-9 in the ischemic hemispheric microvessels up

General Information

EC Number General Information Comment Organism
3.4.24.35 physiological function MMP-9- mediated occludin degradation represents an important mechanism for blood brain barrier disruption in ischemic stroke Rattus norvegicus