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Literature summary extracted from

  • Dreiseitel, A.; Korte, G.; Schreier, P.; Oehme, A.; Locher, S.; Hajak, G.; Sand, P.G.
    sPhospholipase A(2) is inhibited by anthocyanidins (2009), J. Neural Transm., 116, 1071-1077.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.1.1.4 drug development partial inhibition of PLA2-V by most fruit antioxidants may prove advantageous in vivo in that basal levels of phospholipid-derived mediators may be maintained for normal brain function. The sPLA2-V inhibition by anthocyanidins provides further evidence to rationalize antioxidative and antiinflammatory activities Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.1.4
-
 Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.1.4 catechin reaches 50% inhibition at concentrations of 2.5 mM Homo sapiens
3.1.1.4 cyanidin mixed competitive and noncompetitive inhibition, partial hyperbolic type of inhibition Homo sapiens
3.1.1.4 delphinidin mixed competitive and noncompetitive inhibition, complete inhibition Homo sapiens
3.1.1.4 malvidin partial competitive inhibition Homo sapiens
3.1.1.4 additional information anthocyanidins exhibit the best inhibitory effects on PLA2, whereas inhibitory properties of anthocyanins are less pronounced Homo sapiens
3.1.1.4 pelargonidin mixed competitive and noncompetitive inhibition, complete inhibition Homo sapiens
3.1.1.4 peonidin mixed competitive and noncompetitive inhibition, partial hyperbolic type of inhibition Homo sapiens
3.1.1.4 petunidin mixed competitive and noncompetitive inhibition, partial hyperbolic type of inhibition Homo sapiens
3.1.1.4 protocatechuic acid reaches 50% inhibition at concentrations of 3.3 mM Homo sapiens
3.1.1.4 thioetheramide phosphatidylcholine exhibits complete competitive inhibition Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.1.1.4 Ca2+ required for catalysis Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.4 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.4 1,2-bis(heptanoylthio)-glycerophosphocholine + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.1.4 PLA2-V
-
 Homo sapiens
3.1.1.4 secretory phospholipase A2
-
 Homo sapiens
3.1.1.4 sPLA2
-
 Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.1.1.4 0.00059
-
 thioetheramide phosphatidylcholine in an aqueous buffer solution, pH 7.5, containing 94 mM KCl, 9 mM CaCl2, 24 mM Tris and 0.28 mM Triton-X 100 Homo sapiens
3.1.1.4 0.0021
-
 cyanidin in an aqueous buffer solution, pH 7.5, containing 94 mM KCl, 9 mM CaCl2, 24 mM Tris and 0.28 mM Triton-X 100 Homo sapiens
3.1.1.4 0.0064
-
 malvidin in an aqueous buffer solution, pH 7.5, containing 94 mM KCl, 9 mM CaCl2, 24 mM Tris and 0.28 mM Triton-X 100 Homo sapiens
3.1.1.4 0.01
-
 peonidin in an aqueous buffer solution, pH 7.5, containing 94 mM KCl, 9 mM CaCl2, 24 mM Tris and 0.28 mM Triton-X 100 Homo sapiens
3.1.1.4 0.014
-
 petunidin in an aqueous buffer solution, pH 7.5, containing 94 mM KCl, 9 mM CaCl2, 24 mM Tris and 0.28 mM Triton-X 100 Homo sapiens
3.1.1.4 0.018
-
 delphinidin in an aqueous buffer solution, pH 7.5, containing 94 mM KCl, 9 mM CaCl2, 24 mM Tris and 0.28 mM Triton-X 100 Homo sapiens
3.1.1.4 0.325
-
 pelargonidin in an aqueous buffer solution, pH 7.5, containing 94 mM KCl, 9 mM CaCl2, 24 mM Tris and 0.28 mM Triton-X 100 Homo sapiens