Literature summary extracted from

Ding, T.; Li, Z.; Hailemariam, T.; Mukherjee, S.; Maxfield, F.; Wu, M.; Jiang, X.
SMS overexpression and knockdown: Impact on cellular sphingomyelin and diacylglycerol metabolism, and cell apoptosis (2008), J. Lipid Res., 49, 376-385.

Cloned(Commentary)

EC Number	Cloned (Comment)	Organism
2.7.8.27	expressed in Chinese hamster ovary cells	Homo sapiens

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.7.8.27	Homo sapiens	-	-	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2.7.8.27	ceramide + phosphatidylcholine	-	Homo sapiens	sphingomyelin + 1,2-diacyl-sn-glycerol	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
2.7.8.27	SMS1	isoform	Homo sapiens
2.7.8.27	SMS2	isoform	Homo sapiens

General Information

EC Number	General Information	Comment	Organism
2.7.8.27	physiological function	isoforms SMS1 and SMS2 are key factors in the control of sphingomyelin and 1,2-diacyl-sn-glycerol levels within the cell and thus influence apoptosis	Homo sapiens

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Release 2023.1 (January 2023)