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Literature summary extracted from

  • Smit, N.P.; Van Rossum, H.H.; Romijn, F.P.; Sellar, K.J.; Breetveld, M.; Gibbs, S.; Van Pelt, J.
    Calcineurin activity and inhibition in skin and (epi)dermal cell cultures (2008), J. Invest. Dermatol., 128, 1686-1690.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.3.16 cyclosporin A an immunosuppressive drug. 25% inhibition in keratinocytes at 831 nM, 49% in melanocytes Homo sapiens
3.1.3.16 EGTA
-
 Homo sapiens
3.1.3.16 additional information calcineurin inhibition in fibroblasts and keratinocytes may be of influence on the overall functioning of the skin immune system. No inhibition of calcineurin by okadaic acid Homo sapiens
3.1.3.16 pimecrolimus an immunosuppressive drug Homo sapiens
3.1.3.16 tacrolimus an immunosuppressive drug. 89% inhibition in keratinocytes at 124 nM, 74% in fibroblasts, and 75% in melanocytes Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.1.3.16 Ca2+ calcium-dependent protein phosphatase 2B Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.16 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.3.16 blood
-
 Homo sapiens
-
3.1.3.16 fibroblast
-
 Homo sapiens
-
3.1.3.16 fibroblast cell line F0502 cell Homo sapiens
-
3.1.3.16 fibroblast cell line F0503 cell Homo sapiens
-
3.1.3.16 keratinocyte
-
 Homo sapiens
-
3.1.3.16 melanocyte
-
 Homo sapiens
-
3.1.3.16 skin
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.1.3.16 0.0038 0.0077 keratinoyctes Homo sapiens
3.1.3.16 0.0085 0.0127 fibroblasts Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
3.1.3.16 calcineurin
-
 Homo sapiens
3.1.3.16 calcium-dependent protein phosphatase 2B
-
 Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.1.3.16 0.0000004 0.0000013 in fibroblasts Homo sapiens tacrolimus
3.1.3.16 0.000002 0.0000027 in fibroblasts Homo sapiens cyclosporin A
3.1.3.16 0.000006 0.0000201 in fibroblasts Homo sapiens pimecrolimus

General Information

EC Number General Information Comment Organism
3.1.3.16 malfunction calcineurin inhibition in fibroblasts and keratinocytes may be of influence on the overall functioning of the skin immune system Homo sapiens