Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • El Azreq, M.A.; Garceau, V.; Harbour, D.; Pivot-Pajot, C.; Bourgoin, S.G.
    Cytohesin-1 regulates the Arf6-phospholipase D signaling axis in human neutrophils: impact on superoxide anion production and secretion (2010), J. Immunol., 184, 637-649.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.4.4 ADP-ribosylation factor 1 i.e. Arf1, a small G protein, stimulates PLD hydrolytic activity Homo sapiens
3.1.4.4 ADP-ribosylation factor 6 i.e. Arf6, a small G protein, stimulates PLD hydrolytic activity Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.4.4 additional information downregulation of Arf1 and cytohesin-1 by siRNA leads to reduced PLD transphosphatidylation activity, overview Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.4 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.4 neutrophil
-
 Homo sapiens
-
3.1.4.4 PLB-985 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.4 1-O-alkyl-2-lyso-phosphatidylcholine + H2O
-
 Homo sapiens choline + 1-O-alkyl-2-lyso-phosphatidate
-
 ?
3.1.4.4 additional information PLD also performs transphosphatidylation using ethanol as phosphatidyl acceptor Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.4.4 PLD
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
3.1.4.4 physiological function polymorphonuclear neutrophil stimulation with fMLP stimulates small G proteins such as ADP-ribosylation factors Arf1 and Arf6, leading to phospholipase D activation and functions such as degranulation and the oxidative burst, regulation, overview Homo sapiens